Evidence map›Paper›PMID 39061892›Full record

ReviewAntioxidants (Basel, Switzerland)2024

OxInflammatory Responses in the Wound Healing Process: A Systematic Review.

Fernanda Barbosa Lopes, Mariáurea Matias Sarandy, Rômulo Dias Novaes, Giuseppe Valacchi, Reggiani Vilela Gonçalves

Abstract readReview
In one paragraph

Review in Antioxidants (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Immunomodulatory Nanozymes as Programmable Redox-Immune Set-Point Regulators.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. International journal of molecular sciences · 2026
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Cu-CeOFrontiers in bioengineering and biotechnology · 2026
    Article
  20. Verbascoside-richFrontiers in bioengineering and biotechnology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fernanda Barbosa LopesDepartment of General Biology, Federal University of Viçosa, Viçosa 36570-900, Minas Gerais, Brazil.
Mariáurea Matias SarandyDepartment of General Biology, Federal University of Viçosa, Viçosa 36570-900, Minas Gerais, Brazil.ORCID 0000-0003-1313-7877
Rômulo Dias NovaesDepartment of Structural Biology, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil.ORCID 0000-0002-3186-5328
Giuseppe ValacchiPlants for Human Health Institute, Animal Science Department, North Carolina State University, North Carolina Research Campus, Kannapolis, NC 28081, USA.ORCID 0000-0002-8792-0947
Reggiani Vilela GonçalvesDepartment of General Biology, Federal University of Viçosa, Viçosa 36570-900, Minas Gerais, Brazil.ORCID 0000-0002-5831-3590

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-03519-22, APQ-04164-22National Council for Scientific and Technological Development 306733/2023-4National Council for Scientific and Technological Development 310413/2023-0National Council for Scientific and Technological Development 403194/2023-7
6 · The paper itself

Abstract

Significant sums are spent every year to find effective treatments to control inflammation and speed up the repair of damaged skin. This study investigated the main mechanisms involved in the skin wound cure. Consequently, it offered guidance to develop new therapies to control OxInflammation and infection and decrease functional loss and cost issues. This systematic review was conducted using the PRISMA guidelines, with a structured search in the MEDLINE (PubMed), Scopus, and Web of Science databases, analyzing 23 original studies. Bias analysis and study quality were assessed using the SYRCLE tool (Prospero number is CRD262 936). Our results highlight the activation of membrane receptors (IFN-δ, TNF-α, toll-like) in phagocytes, especially macrophages, during early wound healing. The STAT1, IP3, and NF-kβ pathways are positively regulated, while Ca

Indexed as

inflammasomeinflammationoxidative stresswound closure

Identifiers

PMID39061892
PMCPMC11274091

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.