ArticleBioengineering (Basel, Switzerland)2024
Enhancing Early Detection of Sepsis in Neonates through Multimodal Biosignal Integration: A Study of Pulse Oximetry, Near-Infrared Spectroscopy (NIRS), and Skin Temperature Monitoring.
Article in Bioengineering (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Epidemiology, Clinical Microbiology and Antimicrobial Therapy: A Shared Effort Against Infectious Diseases.Antibiotics (Basel, Switzerland) · 2026Article
- Assessment of Cervical IL-6 Levels and Neonatal Inflammatory Response in Preterm Birth Following Preterm Premature Rupture of Membranes.Current issues in molecular biology · 2025Article
- Extremely Premature Infant and Digestive Malformations: Case Report of Atypical Postoperative Journeys.Pediatric reports · 2025Article
- Neurodevelopmental Outcomes in Children Born to Mothers Infected with SARS-CoV-2 During Pregnancy: A Narrative Review.Journal of clinical medicine · 2025Review
- Article
- Post-Discharge Trajectories of Romanian Premature Infants: A Cross-Sectional Analysis of Associated Factors.Children (Basel, Switzerland) · 2025Article
- Predicting Risk for Patent Ductus Arteriosus in the Neonate: A Machine Learning Analysis.Medicina (Kaunas, Lithuania) · 2025Article
- Phase-specific mortality risk of serum lactate thresholds in very low birth weight infants with late-onset sepsis: a retrospective cohort study.Frontiers in medicine · 2025Article
- Article
- Mathematical Models for Ultrasound Elastography: Recent Advances to Improve Accuracy and Clinical Utility.Bioengineering (Basel, Switzerland) · 2024Review
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Authors and funding
7 authors.
Funding
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Abstract
Sepsis continues to be challenging to diagnose due to its non-specific clinical signs and symptoms, emphasizing the importance of early detection. Our study aimed to enhance the accuracy of sepsis diagnosis by integrating multimodal monitoring technologies with conventional diagnostic methods. The research included a total of 121 newborns, with 39 cases of late-onset sepsis, 35 cases of early-onset sepsis, and 47 control subjects. Continuous monitoring of biosignals, including pulse oximetry (PO), near-infrared spectroscopy (NIRS), and skin temperature (ST), was conducted. An algorithm was then developed in Python to identify early signs of sepsis. The model demonstrated the capability to detect sepsis 6 to 48 h in advance with an accuracy rate of 87.67 ± 7.42%. Sensitivity and specificity were recorded at 76% and 90%, respectively, with NIRS and ST having the most significant impact on predictive accuracy. Despite the promising results, limitations such as sample size, data variability, and potential biases were noted. These findings highlight the critical role of non-invasive biosensing methods in conjunction with conventional biomarkers and cultures, offering a strong foundation for early sepsis detection and improved neonatal care. Further research should be conducted to validate these results across different clinical settings.
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