Evidence map›Paper›PMID 39061654›Full record

ReviewDiagnostics (Basel, Switzerland)2024

Perineural Invasion in Cervical Cancer: A Hidden Trail for Metastasis.

Guoqiang Chen, Hao Sun, Yunxia Chen, Li Wang, Ouyi Song, Jili Zhang, Dazhi Li, Xiaojun Liu, Lixia Feng

Abstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Notch1Scientific reports · 2026
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guoqiang ChenDepartment of Obstetrics and Gynecology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China.ORCID 0000-0001-8555-9935
Hao SunDepartment of Obstetrics and Gynecology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China.
Yunxia ChenDepartment of Gynecology, The People's Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University, Shenzhen 518101, China.
Li WangDepartment of Gynecology, The People's Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University, Shenzhen 518101, China.
Ouyi SongDepartment of Gynecology, The People's Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University, Shenzhen 518101, China.
Jili ZhangDepartment of Gynecology, The People's Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University, Shenzhen 518101, China.
Dazhi LiDepartment of Gynecology, The People's Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University, Shenzhen 518101, China.
Xiaojun LiuDepartment of Obstetrics and Gynecology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China.
Lixia FengDepartment of Gynecology, The People's Hospital of Baoan Shenzhen, The Second Affiliated Hospital of Shenzhen University, Shenzhen 518101, China.

Funding

Pyramid Talent Project - Outstanding Young Physician of Second Affiliated Hospital of Naval Medical University YQ719This work is supported by the grants from Medical and Health Research Projects of Baoan District Medical Association BAYXH2023001
6 · The paper itself

Abstract

Perineural invasion (PNI), the neoplastic invasion of nerves, is an often overlooked pathological phenomenon in cervical cancer that is associated with poor clinical outcomes. The occurrence of PNI in cervical cancer patients has limited the promotion of Type C1 surgery. Preoperative prediction of the PNI can help identify suitable patients for Type C1 surgery. However, there is a lack of appropriate preoperative diagnostic methods for PNI, and its pathogenesis remains largely unknown. Here, we dissect the neural innervation of the cervix, analyze the molecular mechanisms underlying the occurrence of PNI, and explore suitable preoperative diagnostic methods for PNI to advance the identification and treatment of this ominous cancer phenotype.

Indexed as

cervical cancerneurotrophic factorsperineural invasionSchwann cellsType C1 surgery

Identifiers

PMID39061654
PMCPMC11275432

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.