ArticleAnimals : an open access journal from MDPI2024
Effect of Guanidinoacetic Acid on Production Performance, Serum Biochemistry, Meat Quality and Rumen Fermentation in Hu Sheep.
Article in Animals : an open access journal from MDPI, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Guanidinoacetic acid enhances Tibetan sheep-meat quality through the gut-muscle axis: insights from metabolome-microbiome integration.Food chemistry. Molecular sciences · 2026Article
- Article
- Effect of Amino Acid Derivatives and Polyphenol Supplementation on Ovine Muscle Growth In Vitro and In Vivo.Muscles (Basel, Switzerland) · 2026Article
- Dietary Guanidinoacetic Acid Improves Meat Tenderness and Antioxidant Capacity in Rabbits via Modulating Muscle Fiber Characteristics and Fat Metabolism.Animals : an open access journal from MDPI · 2026Article
- Cornus officinalis extract modulates rumen microbiome and growth of lambs fed a high-concentrate diet.AMB Express · 2026Article
- Low-Dosage Rumen Unprotected Creatine Precursor During the Transition Period in Single-Bearing Ewes Impacts Dynamic Changes in Muscle and Adipose Mass, Uterine Involution, and Fetal Programming Outcomes.Veterinary sciences · 2026Article
- Rumen-protected guanidinoacetic acid is associated with improved growth performance and altered portal nutrient and hepatic IGF-1 indices in Hu sheep.Frontiers in veterinary science · 2026Article
- Creatine-precursor exposure in ewe twin pregnancy directs metabolic effort and reworks the maternal-fetal vascular system, involving genetic markers that modulate the creatine pathway.Frontiers in veterinary science · 2026Article
- Effects on Rumen Microbial Population and Serum Biochemical Responses to Guanidinoacetic Acid,Animals : an open access journal from MDPI · 2025Article
- Dietary Guanidinoacetic Acid Supplementation Improves Growth Performance of Plateau Yaks Through Plasma Metabolome Modulation.Biology · 2025Article
- Integrated transcriptomic and phenotypic analysis reveals tissue-specific regulatory effects of guanidinoacetic acid in cattle.BMC genomics · 2025Article
- Effect of guanidinoacetic acid on the growth performance, serum biochemical indices and metabolites, intestinal morphology, and intestinal flora of Cherry Valley broiler ducks.Poultry science · 2025Article
- Effect of Guanidinoacetic Acid and Zilpaterol Hydrochloride Feed Additions on Lambs' Productive Performance, Carcass Characteristics, and Blood Chemistry.Animals : an open access journal from MDPI · 2025Article
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Authors and funding
9 authors.
Funding
Abstract
Guanidinoacetic acid (GAA) can effectively improve the metabolism of energy and proteins by stimulating creatine biosynthesis. We present a study exploring the impact of GAA on production performance, serum biochemistry, meat quality and rumen fermentation in Hu sheep. A total of 144 weaned male Hu sheep (body weight 16.91 ± 3.1 kg) were randomly assigned to four groups with three replicates of twelve sheep in each group. The diets were supplemented with 0 (CON), 500 (GAA-1), 750 (GAA-2) and 1000 mg/kg (GAA-3) of GAA (weight of feed), respectively. After a comprehensive 90-day experimental period, we discovered that the supplementation of GAA had a remarkable impact on various muscle parameters. Specifically, it significantly enhanced the average daily growth (ADG) of the animals and improved the shear force and fiber diameter of the muscle, while also reducing the drip loss and muscle fiber density. Furthermore, the addition of GAA to the feed notably elevated the serum concentrations of high-density lipoprotein cholesterol (HDL-C), total protein (TP) and globulin (GLB), as well as the enzyme activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px). Concurrently, there was a decrease in the levels of triglycerides (TG) and malondialdehyde (MDA) in the serum. In addition, GAA decreased the pH and the acetate-to-propionate ratio and increased the total volatile fatty acids (TVFA) and ammoniacal nitrogen (NH
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