Evidence map›Paper›PMID 39061421›Full record

ArticleBrain sciences2024

MRI-Based Inner Ear Assessment and Cochlin Tomoprotein-Based Evaluation of Perilymphatic Fistula in Patients with Sudden Hearing Loss.

Rayoung Kim, Denis Mihailovic, Conrad Riemann, Alexander Kilgué, Christoph Joachim Pfeiffer, Hans-Björn Gehl, Lars-Uwe Scholtz, Ingo Todt

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Article in Brain sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rayoung KimDepartment of Otolaryngology, Head and Neck Surgery, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany.
Denis MihailovicDepartment of Radiology, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany.
Conrad RiemannDepartment of Otolaryngology, Head and Neck Surgery, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany.
Alexander KilguéDepartment of Otolaryngology, Head and Neck Surgery, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany.
Christoph Joachim PfeifferDepartment of Otolaryngology, Head and Neck Surgery, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany.
Hans-Björn GehlDepartment of Radiology, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany.
Lars-Uwe ScholtzDepartment of Otolaryngology, Head and Neck Surgery, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany.
Ingo TodtDepartment of Otolaryngology, Head and Neck Surgery, Medical Faculty OWL, Bielefeld University, Campus Klinikum Bielefeld, Teutoburgerstr. 50, 33604 Bielefeld, Germany.ORCID 0000-0002-4161-8304

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo study the correlation between positive cochlin tomoprotein testing (CTP), magnetic resonance (MR) imaging, and the auditory and vestibular function amongst patients with sudden hearing loss. STUDY

designProspective case series.

methodsWe prospectively examined eight patients who presented with sudden hearing loss (>60 dB) with or without vertigo or tinnitus. We performed an ELISA-based CTP detection test using middle ear lavage samples. In addition to the CTP examination, a magnetic resonance imaging (MRI) examination was performed using different sequences (T1 and a T1 sequence with a contrast medium (CM), a T2 sequence, 4 h delayed intravenous gadolinium-enhanced three-dimensional fluid-attenuated inversion recovery (3D FLAIR)).

resultsAll patients with sudden hearing loss (>60 dB) presented a non-specific contrast enhancement in the cochlea and vestibulum on the affected side on delayed 3D-FLAIR MRI. Four patients had a positive CTP test, suggesting a perilymphatic fistula (PLF). However, no specific MRI signal for a PLF was observed.

conclusionsUsing multimodal diagnostic measures, such as CTP testing and different MRI sequences, no correlation could be found in patients with a PLF.

Indexed as

4 h delayed intravenous gadolinium-enhanced 3D FLAIR MRIcochlin tomoproteinmagnetic resonance imagingperilymphatic fistulasudden hearing loss

Identifiers

PMID39061421
PMCPMC11275193

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.