Evidence map›Paper›PMID 39061297›Full record

ArticleAntibiotics (Basel, Switzerland)2024

Efficacy and Safety of Ceftazidime-Avibactam Alone versus Ceftazidime-Avibactam Plus Fosfomycin for the Treatment of Hospital-Acquired Pneumonia and Ventilator-Associated Pneumonia: A Multicentric Retrospective Study from the SUSANA Cohort.

Marco Fois, Andrea De Vito, Francesca Cherchi, Elena Ricci, Michela Pontolillo, Katia Falasca, Nicolò Corti, Agnese Comelli, Alessandra Bandera, Chiara Molteni and 9 more

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Real-World Antibiotic Strategies for Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Marco FoisUnit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0003-2667-5383
Andrea De VitoUnit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0002-8265-5400
Francesca CherchiUnit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy.
Elena RicciFondazione ASIA Onlus, 20090 Buccinasco, Italy.ORCID 0000-0001-5279-0444
Michela PontolilloClinic of Infectious Diseases, Department of Medicine and Science of Aging, G. D'Annunzio University, Chieti-Pescara, 66100 Chieti, Italy.
Katia FalascaClinic of Infectious Diseases, Department of Medicine and Science of Aging, G. D'Annunzio University, Chieti-Pescara, 66100 Chieti, Italy.ORCID 0000-0002-8795-5410
Nicolò CortiInfectious Disease Unit, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.
Agnese ComelliInfectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Alessandra BanderaInfectious Diseases Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.
Chiara MolteniUnit of Infectious Diseases, "A. Manzoni" Hospital, 23900 Lecco, Italy.ORCID 0000-0003-4746-3750
Stefania PiconiUnit of Infectious Diseases, "A. Manzoni" Hospital, 23900 Lecco, Italy.ORCID 0000-0001-7058-1048
Francesca ColucciInfectious Diseases Unit, AORN Sant'Anna e San Sebastiano, 81100 Caserta, Italy.
Paolo MaggiInfectious Diseases Unit, AORN Sant'Anna e San Sebastiano, 81100 Caserta, Italy.ORCID 0000-0002-8772-0136
Vincenzo BosciaUnit of Infectious Diseases, Garibaldi Hospital, 95124 Catania, Italy.
Aakash FugooahUnit of Infectious Diseases, Garibaldi Hospital, 95124 Catania, Italy.
Sara BenedettiUnit of Infectious Diseases, Santa Maria Hospital, 06129 Perugia, Italy.
Giuseppe Vittorio De SocioUnit of Infectious Diseases, Santa Maria Hospital, 06129 Perugia, Italy.ORCID 0000-0001-8774-4843
Paolo BonfantiInfectious Disease Unit, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.ORCID 0000-0001-7289-8823
Giordano MadedduUnit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy.ORCID 0000-0001-6099-2273

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hospital-acquired pneumonia (HAP) and ventilation-associated pneumonia (VAP) are challenging clinical conditions due to the challenging tissue penetrability of the lung. This study aims to evaluate the potential role of fosfomycin (FOS) associated with ceftazidime/avibactam (CZA) in improving the outcome in this setting. We performed a retrospective study including people with HAP or VAP treated with CZA or CZA+FOS for at least 72 h. Clinical data were collected from the SUSANA study, a multicentric cohort to monitor the efficacy and safety of the newer antimicrobial agents. A total of 75 nosocomial pneumonia episodes were included in the analysis. Of these, 34 received CZA alone and 41 in combination with FOS (CZA+FOS). People treated with CZA alone were older, more frequently male, received a prolonged infusion more frequently, and were less frequently affected by carbapenem-resistant infections (

Indexed as

ceftazidime/avibactamcombinationfosfomycinHAPMDROpneumoniaprolonged infusionVAP

Identifiers

PMID39061297
PMCPMC11273729

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.