Evidence map›Paper›PMID 39061291›Full record

ArticleAntibiotics (Basel, Switzerland)2024

A New Guanidine-Core Small-Molecule Compound as a Potential Antimicrobial Agent against Resistant Bacterial Strains.

Noelia Morata-Moreno, Ramón Pérez-Tanoira, Almudena Del Campo-Balguerias, Fernando Carrillo-Hermosilla, Marcos Hernando-Gozalo, Carlos Rescalvo-Casas, Ana V Ocana, Pedro Segui, Carlos Alonso-Moreno, Francisco C Pérez-Martínez and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Noelia Morata-MorenoDepartment of Otorrinolaringology, Complejo Hospitalario Universitario, 02006 Albacete, Spain.
Ramón Pérez-TanoiraDepartamento de Microbiología Clínica, Hospital Universitario Príncipe de Asturias, 28805 Madrid, Spain.ORCID 0000-0002-9816-3208
Almudena Del Campo-BalgueriasUnidad nanoDrug, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 02008 Albacete, Spain.ORCID 0000-0002-0119-6733
Fernando Carrillo-HermosillaDepartamento de Química Inorgánica, Orgánica y Bioquímica-Centro de Innovación en Química Avanzada (ORFEO-CINQA), Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain.ORCID 0000-0002-1187-7719
Marcos Hernando-GozaloDepartamento de Microbiología Clínica, Hospital Universitario Príncipe de Asturias, 28805 Madrid, Spain.ORCID 0000-0003-2838-7270
Carlos Rescalvo-CasasDepartamento de Microbiología Clínica, Hospital Universitario Príncipe de Asturias, 28805 Madrid, Spain.ORCID 0000-0003-3745-6661
Ana V OcanaInstituto de Investigación en Discapacidades Neurológicas (IDINE), University of Castilla-La Mancha, 02001 Albacete, Spain.
Pedro SeguiDepartment of Otorrinolaringology, Complejo Hospitalario Universitario, 02006 Albacete, Spain.
Carlos Alonso-MorenoUnidad nanoDrug, Centro Regional de Investigaciones Biomédicas, Universidad de Castilla-La Mancha, 02008 Albacete, Spain.ORCID 0000-0002-7588-0781
Francisco C Pérez-MartínezInstituto de Investigación en Discapacidades Neurológicas (IDINE), University of Castilla-La Mancha, 02001 Albacete, Spain.
Milagros Molina-AlarcónInstituto de Investigación en Discapacidades Neurológicas (IDINE), University of Castilla-La Mancha, 02001 Albacete, Spain.ORCID 0000-0001-9279-2698

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The guanidine core has been one of the most studied functional groups in medicinal chemistry, and guanylation reactions are powerful tools for synthesizing this kind of compound. In this study, a series of five guanidine-core small molecules were obtained through guanylation reactions. These compounds were then evaluated against three different strains of

Indexed as

antibacterial effectEscherichia coliguanidinePseudomonas aeruginosaStaphylococcus aureus

Identifiers

PMID39061291
PMCPMC11274109

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.