Evidence map›Paper›PMID 39061290›Full record

ArticleAntibiotics (Basel, Switzerland)2024

A Study on the Effect of Quaternization of Polyene Antibiotics' Structures on Their Activity, Toxicity, and Impact on Membrane Models.

Olga Omelchuk, Anna Tevyashova, Svetlana Efimova, Natalia Grammatikova, Elena Bychkova, George Zatonsky, Lyubov Dezhenkova, Nikita Savin, Svetlana Solovieva, Olga Ostroumova and 1 more

Abstract read
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Mono-Antibiotics (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Olga OmelchukGause Institute of New Antibiotics, 11 B. Pirogovskaya, Moscow 119021, Russia.ORCID 0000-0003-2433-5713
Anna TevyashovaGause Institute of New Antibiotics, 11 B. Pirogovskaya, Moscow 119021, Russia.ORCID 0000-0003-1091-1011
Svetlana EfimovaInstitute of Cytology, The Russian Academy of Sciences, 4 Tikhoretsky Ave., St. Petersburg 194064, Russia.ORCID 0000-0002-2429-2007
Natalia GrammatikovaGause Institute of New Antibiotics, 11 B. Pirogovskaya, Moscow 119021, Russia.
Elena BychkovaGause Institute of New Antibiotics, 11 B. Pirogovskaya, Moscow 119021, Russia.
George ZatonskyGause Institute of New Antibiotics, 11 B. Pirogovskaya, Moscow 119021, Russia.
Lyubov DezhenkovaGause Institute of New Antibiotics, 11 B. Pirogovskaya, Moscow 119021, Russia.
Nikita SavinResearch Laboratory of Biophysics, National University of Science and Technology "MISIS", 4 p.1 Leninsky Pr., Moscow 119049, Russia.ORCID 0000-0001-9199-7229
Svetlana SolovievaGause Institute of New Antibiotics, 11 B. Pirogovskaya, Moscow 119021, Russia.
Olga OstroumovaInstitute of Cytology, The Russian Academy of Sciences, 4 Tikhoretsky Ave., St. Petersburg 194064, Russia.
Andrey ShchekotikhinGause Institute of New Antibiotics, 11 B. Pirogovskaya, Moscow 119021, Russia.ORCID 0000-0002-6595-0811

Funding

Russian Science Foundation 21-74-20102
6 · The paper itself

Abstract

Polyene antibiotics have been used in antifungal therapy since the mid-twentieth century. They are highly valued for their broad spectrum of activity and the rarity of pathogen resistance to their action. However, their use in the treatment of systemic mycoses often results in serious side-effects. Recently, there has been a renewed interest in the development of new antifungal drugs based on polyenes, particularly due to the emergence of highly dangerous pathogenic strains of fungi, such as

Indexed as

antibiofilm activityantifungal activitycalcein leakagedrug discoveryhemolysislipid bilayerspolyene antimycoticsscanning ion conductance microscopysemisynthetic derivatives

Identifiers

PMID39061290
PMCPMC11274224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.