Evidence map›Paper›PMID 39061224›Full record

ArticleCancers2024

Real-World Treatment Patterns and Timeliness of Clinical Care Pathway for Non-Small Cell Lung Cancer Patients in Austria: The PRATER Retrospective Study.

Maximilian Hochmair, Angelika Terbuch, David Lang, Christian Trockenbacher, Florian Augustin, Bahil Ghanim, Dominik Maurer, Hossein Taghizadeh, Christoph Kamhuber, Robert Wurm and 14 more

Abstract read
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Maximilian HochmairDepartment of Respiratory and Critical Care Medicine, Karl Landsteiner Institute of Lung Research and Pulmonary Oncology, Klinik Floridsdorf, 1210 Vienna, Austria.ORCID 0000-0002-8673-2450
Angelika TerbuchDivision of Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
David LangDepartment of Pulmonology, Johannes Kepler University Linz, Kepler University Hospital, 4829 Linz, Austria.ORCID 0000-0002-3098-1554
Christian TrockenbacherDepartment of Pulmonology, Klinikum Wels-Grieskirchen, 4600 Wels, Austria.
Florian AugustinDepartment of Visceral, Transplant and Thoracic Surgery, Medical University Innsbruck, 6020 Innsbruck, Austria.
Bahil GhanimDepartment of General and Thoracic Surgery, University Hospital Krems, 3500 Krems an der Donau, Austria.ORCID 0000-0002-6563-5643
Dominik MaurerDepartment of Pulmonology, Ordensklinikum Elisabethinen Linz, 4020 Linz, Austria.
Hossein TaghizadehDivision of Oncology, Department of Internal Medicine I, University Hospital St. Pölten, 3100 St. Pölten, Austria.
Christoph KamhuberDepartment of Oncology, Kardinal Schwarzenberg Klinikum, 5620 Schwarzach, Austria.
Robert WurmDepartment of Pulmonology, Medical University Graz, 8036 Graz, Austria.ORCID 0009-0006-6222-2188
Jörg LindenmannDivision of Thoracic and Hyperbaric Surgery, Department of Surgery, Medical University of Graz, 8036 Graz, Austria.ORCID 0000-0003-1276-7666
Petra BrazDepartment of Pulmonology, Landesklinikum Hochegg, 2840 Hochegg, Austria.
Tatjana BundaloDepartment of Pulmonology, Landesklinikum Hochegg, 2840 Hochegg, Austria.
Merjem BegicDepartment of Thoracic Surgery, Medical University of Vienna, 8036 Vienna, Austria.
Johanna BauerDepartment of Thoracic Surgery, Medical University of Vienna, 8036 Vienna, Austria.
Patrick ReimannDepartment of Oncology, Landeskrankenhaus Feldkirch, 6800 Feldkirch, Austria.
Nino MüserDepartment of Medicine II with Pneumology, Karl Landsteiner Institute for Lung Research and Pulmonary Oncology, Klinik Ottakring, 1160 Vienna, Austria.ORCID 0009-0004-0412-0947
Florian HuemerDivision of Pulmonology, Klinik Penzing, 1140 Vienna, Austria.
Verena SchlintlDivision of Oncology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
Daniela BianconiMSD, 1100 Vienna, Austria.
Bernhard BaumgartnerDepartment of Pulmonology, Vöcklabruck Hospital, 4840 Vöcklabruck, Austria.
Peter SchenkDepartment of Pulmonology, Landesklinikum Hochegg, 2840 Hochegg, Austria.
Markus RauterDepartment of Pulmonology, Klinikum Klagenfurt Am Woerthersee, 9020 Klagenfurt, Austria.
Konrad HötzeneckerDepartment of Thoracic Surgery, Medical University of Vienna, 8036 Vienna, Austria.

Funding

MSD (Austria) NIS100232
6 · The paper itself

Abstract

This was a retrospective study of the profile and initial treatments of adults diagnosed with early-stage (ES) non-small cell lung cancer (NSCLC) during January 2018-December 2021 at 16 leading hospital institutions in Austria, excluding patients enrolled in clinical trials. In total, 319 patients were enrolled at a planned ~1:1:1 ratio across StI:II:III. Most tested biomarkers were programmed death ligand 1 (PD-L1; 58% expressing), Kirsten rat sarcoma virus (KRAS; 22% positive), and epidermal growth factor receptor (EGFR; 18% positive). Of 115/98/106 StI/II/III patients, 82%/85%/36% underwent surgery, followed by systemic therapy in 9%/45%/47% of those [mostly chemotherapy (ChT)]. Unresected treated StIII patients received ChT + radiotherapy [43%; followed by immune checkpoint inhibitors (ICIs) in 39% of those], ICI ± ChT (35%), and ChT-alone/radiotherapy-alone (22%). Treatment was initiated a median (interquartile range) of 24 (7-39) days after histological confirmation, and 55 (38-81) days after first medical visit. Based on exploratory analyses of all patients newly diagnosed with any stage NSCLC during 2018-2021 at 14 of the sites (N = 7846), 22%/10%/25%/43% had StI/II/III/IV. The total number was not significantly different between pre-COVID-19 (2018-2019) and study-specific COVID-19 (2020-2021) periods, while StI proportion increased (21% vs. 23%;

Indexed as

COVID-19NSCLCpatient pathwayreal-worldstage distributiontime intervalstreatment patterns

Identifiers

PMID39061224
PMCPMC11275022

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.