Evidence map›Paper›PMID 39061135›Full record

ArticleCancers2024

Smell and Taste Alterations in Patients Receiving Curative or Palliative Chemotherapy-The CONKO 021-ChemTox Trial.

Tobias Bleumer, Janine Abel, Wolfgang Böhmerle, Sebastian Schröder, Soo Ann Yap, Nigel Dross Engelbert Schaeper, Thomas Hummel, Sebastian Stintzing, Lars Uwe Stephan, Uwe Pelzer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tobias BleumerDepartment of Hematology, Oncology and Tumor Immunology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Janine AbelDepartment of Hematology, Oncology and Tumor Immunology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Wolfgang BöhmerleDepartment of Neurology and Experimental Neurology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117 Berlin, Germany.ORCID 0000-0001-7195-3894
Sebastian SchröderDepartment of Hematology, Oncology and Tumor Immunology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Soo Ann YapDepartment of Hematology, Oncology and Tumor Immunology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Nigel Dross Engelbert SchaeperDepartment of Hematology, Oncology and Tumor Immunology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Thomas HummelSmell & Taste Clinic, Department of Otorhinolaryngology, Technische Universität Dresden, 01307 Dresden, Germany.ORCID 0000-0001-9713-0183
Sebastian StintzingDepartment of Hematology, Oncology and Tumor Immunology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117 Berlin, Germany.ORCID 0000-0002-3297-5801
Lars Uwe StephanDepartment of Hematology, Oncology and Tumor Immunology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117 Berlin, Germany.
Uwe PelzerDepartment of Hematology, Oncology and Tumor Immunology, Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117 Berlin, Germany.ORCID 0000-0001-9213-2737

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous data regarding chemotherapy-induced olfactory and gustatory dysfunction (CIOGD) are heterogeneous due to inconsistent study designs and small numbers of patients. To provide consistent, reliable data, we conducted a cohort study using standardized testing. Patients diagnosed with lymphoma, leukemia, or gastrointestinal malignancies were examined up to five times (T1 to T5), beginning prior to chemotherapy. We examined patients receiving temporary treatment up to 12 months post-therapy. Clinical assessment included extensive questionnaires, psychophysical tests of olfactory and gustatory function, and measurement of peripheral neuropathy. Statistical analysis included non-parametric tests to evaluate the longitudinal development of CIOGD. Our data (n = 108) showed a significant decline in olfactory and gustatory testing during chemotherapy (

Indexed as

anorexiachemosensory functionchemotherapyCIPNdysgeusiadysosmianeuropathytaste and smell alterations

Identifiers

PMID39061135
PMCPMC11274726

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.