Evidence map›Paper›PMID 39061118›Full record

SynthesisHead & neck2025

Prognostic significance of hemorrhage requiring embolization in the setting of previously treated head and neck squamous cell carcinoma: Systematic review and retrospective cohort.

Omar A Karadaghy, Andrew M Peterson, Tuleen Sawaf, Bryan Renslo, Brevin Miller, Celina Virgen, Kevin J Sykes, Michelle M Doering, Christopher J Moran, Henrik Ullman and 3 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Omar A KaradaghyDepartment of Otolaryngology - Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas, USA.ORCID 0000-0001-6866-5605
Andrew M PetersonDepartment of Otolaryngology - Head and Neck Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.ORCID 0000-0001-9965-1572
Tuleen SawafDepartment of Otolaryngology - Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas, USA.
Bryan RensloDepartment of Otolaryngology - Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas, USA.
Brevin MillerDepartment of Otolaryngology - Head and Neck Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
Celina VirgenDepartment of Otolaryngology - Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas, USA.
Kevin J SykesDepartment of Otolaryngology - Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas, USA.
Michelle M DoeringBecker Medical Library, Washington University School of Medicine in St. Louis, St. Louis, Missouri, USA.
Christopher J MoranDepartment of Radiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Henrik UllmanDepartment of Radiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Jeremy PetersonDepartment of Otolaryngology - Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas, USA.
Patrik PipkornDepartment of Otolaryngology - Head and Neck Surgery, Washington University in St. Louis, St. Louis, Missouri, USA.
Andrés M BurDepartment of Otolaryngology - Head and Neck Surgery, University of Kansas School of Medicine, Kansas City, Kansas, USA.ORCID 0000-0001-6879-6453

Funding

Using Integrated Omics to Identify Dysfunctional Genetic Mechanisms Influencing Schizophrenia and Sleep DisturbancesP20GM130423 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Kalyani Pyaram, Steven Allan Soper · 2019 to 2026
$21.5M
NIGMS NIH HHS P20 GM130423
6 · The paper itself

Abstract

backgroundThe management of acute hemorrhage in patients with previously treated head and neck squamous cell carcinoma (HNSCC) is challenging due to the lack of substantial evidence to guide clinical decision making.

methodsA systematic review and retrospective chart review were performed to identify patients with a history of HNSCC who underwent either primary or adjuvant radiation therapy (RT) and presented with hemorrhagic complications requiring embolization. Patient characteristics, history, presentation, and outcomes were reviewed.

resultsThe systematic review included a total of 182 patients. Heterogeneity existed in outcomes reporting; 1-year overall survival approached 50%. From the retrospective chart review, 51 patients were included. Median survival time following hemorrhage was 2.2 months (range 1.2-11.4 months). Patients with malignancy at time of hemorrhage were identified as having worse survival.

conclusionsAcute hemorrhage in patients with a history of previously radiated HNSCC portends a high risk of mortality, with patients with active malignancy representing a worse prognostic group.

Indexed as

Embolization, TherapeuticHead and Neck NeoplasmsHemorrhageSquamous Cell Carcinoma of Head and NeckAgedFemaleHumansMaleMiddle AgedPrognosisRetrospective Studiesembolizationhemorrhageradionecrosissurvivalupper aerodigestive track

Identifiers

PMID39061118
PMCPMC12375220

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.