Evidence map›Paper›PMID 39061072›Full record

ArticleItalian journal of pediatrics2024

Prevalence of delivery mode in an Italian nationwide cohort with celiac disease: a SIGENP multicenter retrospective study (the CD-deliver-IT).

Donatella Iorfida, Francesco Valitutti, Annarita Vestri, Grazia D'Adamo, Tiziana Passaro, Marco Crocco, Federica Malerba, Alice Monzani, Ivana Rabbone, Licia Pensabene and 11 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Italian journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Donatella IorfidaDepartment of Maternal and Child Health, Pediatrics and Neonatology Unit, Santa Maria Goretti Hospital, Sapienza - University of Rome, Latina, Italy.
Francesco ValituttiDepartment of Surgical and Biomedical Sciences, Pediatric Clinic, University of Perugia, Perugia, Italy.
Annarita VestriDepartment of Public Health and Infectious Disease, Sapienza - University of Rome, Rome, Italy.
Grazia D'AdamoPediatric Unit, AOU Salerno, P.O. Cava de' Tirreni, Salerno, Italy.
Tiziana PassaroPediatric Unit, AOU Salerno, P.O. Cava de' Tirreni, Salerno, Italy.
Marco CroccoPediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini, Genoa, 16147, Italy.
Federica MalerbaPediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini, Genoa, 16147, Italy.
Alice MonzaniDepartment of Health Sciences, Division of Paediatrics, University of Piemonte Orientale, Novara, Italy.
Ivana RabboneDepartment of Health Sciences, Division of Paediatrics, University of Piemonte Orientale, Novara, Italy.
Licia PensabeneDepartment of Surgical and Medical Sciences, Pediatric Unit, Magna Graecia University, Catanzaro, Italy.
Laura GiancottiDepartment of Surgical and Medical Sciences, Pediatric Unit, Magna Graecia University, Catanzaro, Italy.
Francesco GrazianoPediatric Unit, Villa Sofia - Cervello Hospital, Palermo, Italy.
Michele CitranoPediatric Unit, Villa Sofia - Cervello Hospital, Palermo, Italy.
Francesca FerrettiHepatology Gastroenterology and Nutrition Unit, Bambino Gesù Children Hospital, Rome, Italy.
Chiara Maria TrovatoHepatology Gastroenterology and Nutrition Unit, Bambino Gesù Children Hospital, Rome, Italy.
Caterina PacenzaPediatric Unit, "S. Giovanni di Dio" Hospital, Crotone, Italy.
Mario IasevoliDepartment of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Pediatrics Section, University of Salerno, Baronissi, Italy.
Claudia BanzatoPediatric Division, University of Verona, Verona, Italy.
Riccardo LubranoDepartment of Maternal and Child Health, Pediatrics and Neonatology Unit, Santa Maria Goretti Hospital, Sapienza - University of Rome, Latina, Italy.
Monica MontuoriMaternal and Child Health Department, Pediatric Gastroenterology and Liver Unit, Sapienza - University of Rome, Rome, Italy. m.montuori@policlinicoumberto1.it.ORCID http://orcid.org/0000-0003-2383-5177
“Food-induced disease” study group of SIGENP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have indicated an association between cesarean section (CS), especially elective CS, and an increased risk of celiac disease (CD), but the conclusions of other studies are contradictory. The primary aim of this study (CD-deliver-IT) was to evaluate the rate of CS in a large population of CD patients throughout Italy. 

methodsThis national multicenter retrospective study was conducted between December 2020 and November 2021. The coordinating center was the Pediatric Gastroenterology and Liver Unit of Policlinico Umberto I, Sapienza, University of Rome, Lazio, Italy. Eleven other referral centers for CD have participated to the study. Each center has collected data on mode of delivery and perinatal period of all CD patients referring to the center in the last 40 years.

resultsOut of 3,259 CD patients recruited in different Italian regions, data on the mode of delivery were obtained from 3,234. One thousand nine hundred forty-one (1,941) patients (60%) were born vaginally and 1,293 (40%) by CS (8.3% emergency CS, 30.1% planned CS, 1.5% undefined CS). A statistically significant difference was found comparing median age at time of CD diagnosis of patients who were born by emergency CS (4 years, CI 95% 3.40-4.59), planned CS (7 years, CI 95% 6.02-7.97) and vaginal delivery (6 years, CI 95% 5.62-6.37) (log rank p < 0.0001).

conclusionsThis is the first Italian multicenter study aiming at evaluating the rate of CS in a large population of CD patients through Italy. The CS rate found in our CD patients is higher than rates reported in the general population over the last 40 years and emergency CS seems to be associated with an earlier onset of CD compared to vaginal delivery or elective CS in our large nationwide retrospective cohort. This suggests a potential role of the mode of delivery on the risk of developing CD and on its age of onset, but it is more likely that it works in concert with other perinatal factors. Further prospective studies on other perinatal factors potentially influencing gut microbiota are awaited in order to address heavy conflicting evidence reaming in this research field.

Indexed as

Celiac DiseaseCesarean SectionDelivery, ObstetricAdultChildChild, PreschoolFemaleHumansItalyMalePregnancyPrevalenceRetrospective StudiesCeliac diseaseCesarean sectionGut microbiotaMode of delivery

Identifiers

PMID39061072
PMCPMC11282831

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.