ArticleBiomechanics and modeling in mechanobiology2024
Mechanobiological optimization of scaffolds for bone tissue engineering.
Article in Biomechanics and modeling in mechanobiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Metallic topological structures in bone repair implants: Design, properties, and biological interactions.Journal of orthopaedic translation · 2026Review
- Numerical study of the structural design influence on cartilage cell differentiation in mechanically stimulated hydrogel scaffolds using an FSI-based model.Biomechanics and modeling in mechanobiology · 2025Article
- Tuning the trabecular orientation of Voronoi-based scaffold to optimize the micro-environment for bone healing.Biomechanics and modeling in mechanobiology · 2025Article
- A Novel Triad of Bio-Inspired Design, Digital Fabrication, and Bio-Derived Materials for Personalised Bone Repair.Materials (Basel, Switzerland) · 2024Review
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Authors and funding
2 authors.
Funding
Abstract
Synthetic bone graft scaffolds aim to generate new bone tissue and alleviate the limitations of autografts and allografts. To meet that aim, it is essential to have a design approach able to generate scaffold architectures that will promote bone formation. Here, we present a topology-varying design optimization method, the "mixed-topology" approach, that generates new designs from a set of starting structures. This approach was used with objective functions focusing on improving the scaffold's local mechanical microenvironments to mechanobiologically promote bone formation within the scaffold and constraints to ensure manufacturability and achieve desired macroscale properties. The results demonstrate that this approach can successfully generate scaffold designs with improved microenvironments, taking into account different combinations of relevant stimuli and constraints.
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