Translocase of Outer Mitochondrial Membrane 40, as a Promising Biomarker for the Diagnosis of Polycystic Ovary Syndrome and Pan-Cancer.

Xin Zhang, Lin Zhu, ChenHao Ma, Shu-Ning Zhao, Chu-Yue Zhao, Hui Sun

Abstract read

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Article in Reproductive sciences (Thousand Oaks, Calif.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Xin Zhang *Department of Laboratory Diagnosis, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.

Lin Zhu *Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal- Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

ChenHao MaPharmaceutical Experiment Teaching Center, College of Pharmacy, Harbin Medical University, NO.194, BaoJian Street, Nan Gang District, Harbin, Heilongjiang, 150081, P. R. China.

Shu-Ning ZhaoPharmaceutical Experiment Teaching Center, College of Pharmacy, Harbin Medical University, NO.194, BaoJian Street, Nan Gang District, Harbin, Heilongjiang, 150081, P. R. China.

Chu-Yue ZhaoPharmaceutical Experiment Teaching Center, College of Pharmacy, Harbin Medical University, NO.194, BaoJian Street, Nan Gang District, Harbin, Heilongjiang, 150081, P. R. China.

Hui SunPharmaceutical Experiment Teaching Center, College of Pharmacy, Harbin Medical University, NO.194, BaoJian Street, Nan Gang District, Harbin, Heilongjiang, 150081, P. R. China. sunhui@hrbmu.edu.cn.ORCID 0009-0007-9351-6549

Funding

National Conference on Undergraduate Innovation and Entrepreneurship under Grant Agreement No.202310226122

6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is a metabolic disease that affects the reproductive system, and its pathogenesis remains unresolved. Through the application of bioinformatics and molecular biology techniques, this study has identified a significant association between translocase of outer mitochondrial membrane 40 (TOMM40) and both PCOS and pan-cancers. The selection of PCOS biomarkers included TOMM40, which we found to be significantly decreased in the PCOS group both in vitro and in vivo, using molecular biology methods such as Western Blot as well as immunohistochemistry. Over-expression TOMM40 can rescue the effect on apoptosis rate and proliferation suppression induced by DHEA in KGN cells. TOMM40 as a biomarker for the diagnosis of PCOS. The pan-cancer analysis revealed an association between elevated TOMM40 expression in Uterine Corpus Endometrial Carcinoma and an unfavorable prognosis, while increased TOMM40 expression in six tumor types was linked to a favorable prognosis. Therefore, TOMM40 can be regarded as a promising biomarker for diagnosing both PCOS and pan-cancer.

Indexed as

Mitochondrial Precursor Protein Import Complex ProteinsPolycystic Ovary SyndromeAnimalsApoptosisBiomarkers, TumorCell Line, TumorCell ProliferationFemaleHumansMembrane Transport ProteinsNeoplasmsPrognosisBiomarkers, TumorMembrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsTOMM40 protein, humanMachine learningPan-cancerPCOSTOMM40

Identifiers

PMID39060752

DOI10.1038/s41571-020-0426-7

PMCPMC11527956

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.