Evidence map›Paper›PMID 39060674›Full record

ArticleJapanese journal of ophthalmology2024

Intraocular kinetics of pathological ATP after photoreceptor damage in rhegmatogenous retinal detachment.

Takashi Tachibana, Shoji Notomi, Jun Funatsu, Kohta Fujiwara, Shunji Nakatake, Yusuke Murakami, Shintaro Nakao, Takashi Kanamoto, Yasuhiro Ikeda, Tatsuro Ishibashi and 2 more

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In one paragraph

Article in Japanese journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Takashi TachibanaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shoji NotomiDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Jun FunatsuDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kohta FujiwaraDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shunji NakatakeDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yusuke MurakamiDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shintaro NakaoDepartment of Ophthalmology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Takashi KanamotoMiharaeki-Kanamoto Eye Clinic, Hiroshima, Japan.
Yasuhiro IkedaDepartment of Ophthalmology, Faculty of Medicine, Miyazaki University, Miyazaki, Japan.
Tatsuro IshibashiDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Koh-Hei SonodaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Toshio HisatomiDepartment of Ophthalmology, Fukuoka University Chikushi Hospital, 1-1-1 Zokumyouin, Chikushino, Fukuoka, 818-8502, Japan. t.hisatomi.qk@fukuoka-u.ac.jp.ORCID http://orcid.org/0000-0003-2552-9595

Funding

Japanese Ophthalmological Society Council Award 2020Japan Society for the Promotion of Science JP17K11455
6 · The paper itself

Abstract

purposeExtracellular Adenosine triphosphate (ATP) released by dying cells may cause a secondary cell death in neighboring cells in retinal degeneration. We investigated intraocular ATP kinetics to gain mechanical insights into the pathology in rhegmatogenous retinal detachment (RRD). STUDY

designRetrospective clinical study.

methodsVitreous or subretinal fluids (SRF) were obtained from patients with RRD (n=75), macular hole (MH; n=20), and epiretinal membrane (ERM; n=35) during vitrectomy. ATP levels in those samples were measured by luciferase assay.

resultsMean ATP levels in the vitreous from RRD patients were significantly higher compared to those from MH and ERM patients (2.3 and 0.3 nM, respectively. P<0.01). Mean ATP levels in the SRF from RRD (11.7 nM) were higher than those in the vitreous from RRD (P<0.01). Mean ATP levels in the vitreous with short durations (1-8 days) of RRD were higher compared to those with long durations (>8 days) (3.2 and 1.4 nM, respectively. P<0.05). Similarly, ATP in SRF with short durations were higher than those with long durations (23.8 and 3.6 nM, respectively. P<0.05). Furthermore, the concentrations of ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1), a major ATP degradative enzyme, in the vitreous from RRD were higher than those from MH/ERM (1.2 and 0.2 ng/ml, respectively. P<0.01). ENTPD1 expression was localized in the cytoplasm of CD11b-positive infiltrating cells in the vitreous and retinal cells.

conclusionATP increased in the vitreous and SRF in RRD and decreased over time with an upregulation of ENTPD1. The kinetics indicate the pathological mechanism of the excessive extracellular ATP after RRD.

Indexed as

Adenosine TriphosphateRetinal DetachmentVitrectomyVitreous BodyAgedFemaleHumansKineticsMaleMiddle AgedPhotoreceptor Cells, VertebrateRetrospective StudiesSubretinal FluidAdenosine TriphosphateAdenosine-5’-triphosphate (ATP)Adenosine diphosphate (ADP)And pars plana vitrectomyApoptosisRhegmatogenous retinal detachment (RRD)

Identifiers

PMID39060674

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.