Evidence map›Paper›PMID 39060559›Full record

ArticleCell biology and toxicology2024

Adenosine kinase protects against acetaminophen-induced acute liver injury by activating autophagy in hepatocytes.

Chuanxin Zhang, Xuehao Liu, Xilong Liu, Rui Hua, Han Liu, Jiaxin Ma, Dan Zou, Guangmei Wang, Qiuhuan Yuan, Bailu Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biology and toxicology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Chuanxin ZhangDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Xuehao LiuDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Xilong LiuDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Rui HuaDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Han LiuDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Jiaxin MaDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Dan ZouDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Guangmei WangDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Qiuhuan YuanDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Bailu WangNMPA Key Laboratory for Clinical Research and Evaluation of Innovative Drug, Clinical Trial Center, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China.
Shujian WeiDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China. weishujian@sdu.edu.cn.
Yuguo ChenDepartment of Emergency and Chest Pain Center, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China. chen919085@sdu.edu.cn.

Funding

Clinical Research Foundation of Shandong University 2020SDUCRCC014National Key R&D Program of China 2020YFC1512700National Natural Science Foundation of China 82072141Natural Science Foundation of Shandong Province ZR2022QH225Taishan Pandeng Scholar Program of Shandong Province tspd20181220the State Key Program of the National Natural Science Foundation of China 82030059
6 · The paper itself

Abstract

Acute liver injury (ALI) is a common life-threatening condition with a high mortality rate due to liver disease-related death. However, current therapeutic interventions for ALI remain ineffective, and the development of effective novel therapies is urgently needed. Liver samples from patients with drug-induced ALI were collected to detect adenosine kinase (ADK) expression. Male C57BL/6 J mice, hepatocyte-specific ADK knockout (ADK

Indexed as

AcetaminophenAdenosine KinaseAutophagyChemical and Drug Induced Liver InjuryHepatocytesSignal TransductionAMP-Activated Protein KinasesAnimalsHumansLiverMaleMiceMice, Inbred C57BLMice, KnockoutTOR Serine-Threonine KinasesAcetaminophenAdenosine KinaseAMP-Activated Protein KinasesTOR Serine-Threonine KinasesAcute liver injuryAdenosine kinaseAdenosine receptor A1AutophagymTOR

Identifiers

PMID39060559
PMCPMC11281981

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.