Evidence map›Paper›PMID 39060501›Full record

ArticleNature genetics2024

Competition shapes the landscape of X-chromosome-linked genetic diversity.

Teresa Buenaventura, Hakan Bagci, Ilinca Patrascan, Joshua J Graham, Kelsey D Hipwell, Roel Oldenkamp, James W D King, Jesus Urtasun, George Young, Daniel Mouzo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Teresa BuenaventuraMRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Hakan BagciMRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Ilinca PatrascanMRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-2740-6767
Joshua J GrahamLeicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.ORCID http://orcid.org/0009-0008-6485-2604
Kelsey D HipwellLeicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.ORCID http://orcid.org/0009-0002-0460-7849
Roel OldenkampDivision of Cell Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
James W D KingMRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Jesus UrtasunMRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
George YoungMRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-1203-588X
Daniel MouzoTranslational Bioinformatics Unit, Navarrabiomed, Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.ORCID http://orcid.org/0000-0002-0383-5703
David Gomez-CabreroTranslational Bioinformatics Unit, Navarrabiomed, Universidad Pública de Navarra (UPNA), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.
Benjamin D RowlandDivision of Cell Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID http://orcid.org/0000-0002-0694-8463
Daniel PanneLeicester Institute of Structural and Chemical Biology, Department of Molecular and Cell Biology, University of Leicester, Leicester, UK.
Amanda G FisherMRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK.
Matthias MerkenschlagerMRC LMS, Institute of Clinical Sciences, Faculty of Medicine, Imperial College London, London, UK. matthias.merkenschlager@lms.mrc.ac.uk.ORCID http://orcid.org/0000-0003-2889-3288

Funding

RCUK | Medical Research Council (MRC) LMS Institute FundingWellcome TrustWellcome Trust (Wellcome) 099276/Z/12/Z
6 · The paper itself

Abstract

X chromosome inactivation (XCI) generates clonal heterogeneity within XX individuals. Combined with sequence variation between human X chromosomes, XCI gives rise to intra-individual clonal diversity, whereby two sets of clones express mutually exclusive sequence variants present on one or the other X chromosome. Here we ask whether such clones merely co-exist or potentially interact with each other to modulate the contribution of X-linked diversity to organismal development. Focusing on X-linked coding variation in the human STAG2 gene, we show that Stag2

Indexed as

Chromosomes, Human, XGenes, X-LinkedGenetic VariationX Chromosome InactivationAnimalsAntigens, NuclearCell Cycle ProteinsCohesinsFemaleHumansLymphocytesMiceX ChromosomeAntigens, NuclearCell Cycle ProteinsCohesinsSTAG2 protein, human

Identifiers

PMID39060501
PMCPMC11319201

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.