Evidence map›Paper›PMID 39060494›Full record

ArticleEuropean radiology2025

Free-breathing 3D phase-resolved functional lung MRI vs breath-hold hyperpolarized

Filip Klimeš, Agilo Luitger Kern, Andreas Voskrebenzev, Marcel Gutberlet, Robert Grimm, Robin Aaron Müller, Lea Behrendt, Till Frederik Kaireit, Julian Glandorf, Tawfik Moher Alsady and 3 more

Abstract readComparative Study
In one paragraph

Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Functional Pulmonary Imaging.Journal of magnetic resonance imaging : JMRI · 2025
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Filip KlimešInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany.
Agilo Luitger KernInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany.
Andreas VoskrebenzevInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany.
Marcel GutberletInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany.
Robert GrimmMR Application Predevelopment, Siemens Healthineers AG, Erlangen, Germany.
Robin Aaron MüllerInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany.
Lea BehrendtInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany.
Till Frederik KaireitInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany.
Julian GlandorfInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany.
Tawfik Moher AlsadyInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany.
Frank WackerInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany.
Jens M HohlfeldBiomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Centre for Lung Research, Hanover, Germany.
Jens Vogel-ClaussenInstitute of Diagnostic and Interventional Radiology, Hannover Medical School, Hanover, Germany. vogel-claussen.jens@mh-hannover.de.ORCID http://orcid.org/0000-0001-5595-6948

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectives3D phase-resolved functional lung (PREFUL) MRI offers evaluation of pulmonary ventilation without inhalation of contrast agent. This study seeks to compare ventilation maps obtained from 3D PREFUL MRI with a direct ventilation measurement derived from

methodsThirty-one patients with COPD and 12 healthy controls underwent free-breathing 3D PREFUL MRI and breath-hold

resultsOn a global level, all 3D PREFUL VDP values correlated significantly to VDP measure derived by

conclusionsFree-breathing 3D PREFUL MRI showed a strong correlation with breath-hold hyperpolarized CLINICAL RELEVANCE STATEMENT: 3D PREFUL MRI correlated with KEY POINTS: Current non-invasive evaluation techniques for lung diseases have drawbacks;

Indexed as

Imaging, Three-DimensionalLungMagnetic Resonance ImagingPulmonary Disease, Chronic ObstructiveAgedBreath HoldingCase-Control StudiesFemaleHealthy VolunteersHumansMaleMiddle AgedPulmonary VentilationXenon IsotopesXenon-129Xenon IsotopesChronic obstructive pulmonary diseaseLungMagnetic resonance imagingVentilation

Identifiers

PMID39060494
PMCPMC11782336

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.