Evidence map›Paper›PMID 39060491›Full record

ArticleEuropean radiology2025

Dilated lenticulostriate artery on whole-brain vessel wall imaging differentiates pathogenesis and predicts clinical outcomes in single subcortical infarction.

Jin Li, Junxia Niu, Weimin Zheng, Yueyan Bian, Fang Wu, Xiuqin Jia, Zhaoyang Fan, Xihai Zhao, Qi Yang

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Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

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2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Jin Li *Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Junxia Niu *Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Weimin ZhengDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Yueyan BianDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Fang WuDepartment of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Xiuqin JiaDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Zhaoyang FanDepartment of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Xihai ZhaoCenter for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China.
Qi YangDepartment of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. yangyangqiqi@gmail.com.ORCID http://orcid.org/0000-0002-5773-0456

Funding

Capital's Funds for Health Improvement and Research 2022-1-2031National Natural Science Foundation of China 82025018
6 · The paper itself

Abstract

objectivesThis study aimed to investigate the dilation of lenticulostriate artery (LSA) identified by whole-brain vessel wall imaging (WB-VWI) in differentiating the etiologic subtypes of single subcortical infarction (SSI) and to determine whether the appearance of dilated LSA was associated with 90-day clinical outcomes in parental atherosclerotic disease (PAD)-related SSI.

methodsPatients with acute SSI were prospectively enrolled and categorized into PAD-related SSI and cerebral small-vessel disease (CSVD)-related SSI groups. The imaging features of LSA morphology (branches, length, dilation, and tortuosity), plaques (burden, remodeling index, enhancement degree, and hyperintense plaque), and CSVD (white matter hyperintensity, lacunes, cerebral microbleed, and enlarged perivascular space) were evaluated. The logistic regression was performed to determine the association of dilated LSA with PAD-related SSI and 90-day clinical outcomes.

resultsIn total, 131 patients (mean age, 52.2 ± 13.2 years; 99 men) were included. The multivariate logistic regression analysis revealed that the presence of dilated LSAs (odds ratio (OR), 7.40; 95% confidence interval (CI): 1.88-29.17; p = 0.004)) was significantly associated with PAD-related SSI. Moreover, after adjusting for confounding factors, the association of poor outcomes with the total length of LSAs (OR, 0.94; 95% CI: 0.90-0.99; p = 0.011), dilated LSAs (OR, 0.001; 95% CI: 0.0001-0.08; p = 0.002), and plaque burden (OR, 1.35; 95% CI: 1.11-1.63; p = 0.002) remained statistically significant.

conclusionThe dilation of LSA visualized on WB-VWI could differentiate various subtypes of SSI within LSA territory and was a prognostic imaging marker for 90-day clinical outcomes for PAD-related SSI. CLINICAL RELEVANCE STATEMENT: Evaluation of LSA morphology based on WB-VWI can differentiate the pathogenesis and predict clinical outcomes in SSI, providing crucial insights into the etiologic mechanisms, risk stratification, and tailored therapies for these patients. KEY POINTS: The prognosis of SSIs within lenticulostriate territory depend on the etiology of the disease. LSA dilation on WB-VWI was associated with parental atherosclerosis and better 90-day outcomes. Accurately identifying the etiology of SSIs in lenticulostriate territory assists in treatment decision-making.

Indexed as

Basal Ganglia Cerebrovascular DiseaseCerebral InfarctionAdultAgedBrainFemaleHumansMaleMiddle AgedPrognosisProspective StudiesAtherosclerosisCerebral small-vessel diseaseLenticulostriate arterySingle subcortical infarctionWhole-brain vessel wall imaging

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PMID39060491

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.