Evidence map›Paper›PMID 39060438›Full record

ArticleActa neuropathologica2024

High throughput spatial immune mapping reveals an innate immune scar in post-COVID-19 brains.

Marius Schwabenland, Dilara Hasavci, Sibylle Frase, Katharina Wolf, Nikolaus Deigendesch, Joerg M Buescher, Kirsten D Mertz, Benjamin Ondruschka, Hermann Altmeppen, Jakob Matschke and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Human brain matters: Navigating the neuropathology of COVID-19.Brain pathology (Zurich, Switzerland) · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Neuroimmune pathophysiology of long COVID.Psychiatry and clinical neurosciences · 2025
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Marius SchwabenlandInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany.ORCID 0000-0003-2205-5427
Dilara HasavciInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany.
Sibylle FraseDepartment of Neurology and Neuroscience, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Katharina WolfDepartment of Neurology and Neuroscience, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Nikolaus DeigendeschInstitute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.ORCID 0000-0002-6036-3327
Joerg M BuescherMax Planck Institute for Immunobiology and Epigenetics, 79108, Freiburg, Germany.
Kirsten D MertzInstitute of Pathology, Cantonal Hospital Baselland, Liestal, Switzerland.
Benjamin OndruschkaInstitute of Legal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Hermann AltmeppenInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Jakob MatschkeInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Markus GlatzelInstitute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Stephan FrankDivision of Neuropathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.
Robert ThimmeClinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.
Juergen BeckDepartment of Neurosurgery, University Medical Center Freiburg, Freiburg, Germany.
Jonas A HospDepartment of Neurology and Neuroscience, University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Thomas BlankInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany.
Bertram BengschClinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Disease, Faculty of Medicine, University Medical Center Freiburg, Freiburg, Germany.
Marco PrinzInstitute of Neuropathology, Faculty of Medicine, University of Freiburg, Breisacher Str. 64, 79106, Freiburg, Germany. marco.prinz@uniklinik-freiburg.de.ORCID 0000-0002-0349-1955

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The underlying pathogenesis of neurological sequelae in post-COVID-19 patients remains unclear. Here, we used multidimensional spatial immune phenotyping and machine learning methods on brains from initial COVID-19 survivors to identify the biological correlate associated with previous SARS-CoV-2 challenge. Compared to healthy controls, individuals with post-COVID-19 revealed a high percentage of TMEM119

Indexed as

BrainCOVID-19Immunity, InnateAdultAgedCD8-Positive T-LymphocytesCicatrixFemaleHumansMachine LearningMaleMicrogliaMiddle AgedSARS-CoV-2COVID-19Imaging mass cytometryLong-COVIDMicrogliaNeuro-long-COVID-19PACSPCCPost-acute COVID syndromePost-COVID conditionSARS-CoV-2

Identifiers

PMID39060438
PMCPMC11281987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.