Evidence map›Paper›PMID 39060347›Full record

ArticleCommunications biology2024

Endoplasmic reticulum unfolded protein response transcriptional targets of XBP-1s mediate rescue from tauopathy.

Sarah M Waldherr, Marina Han, Aleen D Saxton, Taylor A Vadset, Pamela J McMillan, Jeanna M Wheeler, Nicole F Liachko, Brian C Kraemer

Abstract read
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Diabetic retinopathy and Alzheimer's disease: Convergence of the unfolded protein response in neurodegeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah M WaldherrGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.ORCID 0000-0002-8873-4185
Marina HanDivision of Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA, 98104, USA.
Aleen D SaxtonGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.
Taylor A VadsetGraduate Program in Neuroscience, University of Washington, Seattle, WA, 98195, USA.
Pamela J McMillanDepartment of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, 98195, USA.
Jeanna M WheelerGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.
Nicole F LiachkoGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA.
Brian C KraemerGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, 98108, USA. kraemerb@u.washington.edu.ORCID 0000-0002-2252-7634

Funding

Neurobehavior, Neuropathology, and Risk Factors in Alzheimer's DiseaseT32AG052354 · NIA · UNIVERSITY OF WASHINGTON · PI Brian C. Kraemer, ELAINE R. PESKIND · 2016 to 2026
$6.7M
Developing Neuroprotective Strategies for Tau and TDP-43 Proteinopathy in FTLDR01NS064131 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI KRAEMER, BRIAN C. · 2009 to 2022
$5.0M
Protection from pathological tau by activation of the ER unfolded protein responseR01AG066211 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI KRAEMER, BRIAN C. · 2020 to 2024
$2.7M
TDP-43 in Alzheimer's diseaseR01AG066729 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI LIACHKO, NICOLE FARON · 2021 to 2025
$2.6M
BLRD VA I01 BX005762NIA NIH HHS R01 AG066211NIA NIH HHS R01 AG066729NIA NIH HHS T32 AG052354U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS064131
6 · The paper itself

Abstract

Pathological tau disrupts protein homeostasis (proteostasis) within neurons in Alzheimer's disease (AD) and related disorders. We previously showed constitutive activation of the endoplasmic reticulum unfolded protein response (UPR

Indexed as

Animals, Genetically ModifiedCaenorhabditis elegansCaenorhabditis elegans ProteinsTauopathiesUnfolded Protein ResponseAnimalsCarrier ProteinsDisease Models, AnimalEndoplasmic ReticulumGene Expression RegulationHumanstau ProteinsTranscription FactorsX-Box Binding Protein 1Caenorhabditis elegans ProteinsCarrier Proteinstau ProteinsTranscription FactorsX-Box Binding Protein 1XBP-1 protein, C elegans

Identifiers

PMID39060347
PMCPMC11282107

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.