Evidence map›Paper›PMID 39060278›Full record

ArticleNature communications2024

Multiple embryonic sources converge to form the pectoral girdle skeleton in zebrafish.

Shunya Kuroda, Robert L Lalonde, Thomas A Mansour, Christian Mosimann, Tetsuya Nakamura

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Shared competence forms the basis of gill arch and paired fin serial homology.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shunya Kuroda *Department of Genetics, Rutgers the State University of New Jersey, Piscataway, NJ, 08854, USA. kurodashunya@gmail.com.ORCID 0000-0003-4820-2165
Robert L Lalonde *Department of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-1803-0983
Thomas A MansourDepartment of Genetics, Rutgers the State University of New Jersey, Piscataway, NJ, 08854, USA.
Christian MosimannDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-0749-2576
Tetsuya NakamuraDepartment of Genetics, Rutgers the State University of New Jersey, Piscataway, NJ, 08854, USA. nakamura@dls.rutgers.edu.ORCID 0000-0003-0183-1685

Funding

Decoding the transcriptional mechanisms of pericardium formationR01HL168097 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI Christian Mosimann · 2024 to 2026
$1.7M
Mechanisms of human appendicular and cardiovascular comorbidities: An analysis of heterogeneity and lineage trajectories of the lateral plate mesodermK99HL168148 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI LALONDE, ROBERT L · 2023 to 2024
$199k
NHLBI NIH HHS K99 HL168148NHLBI NIH HHS R01 HL168097
6 · The paper itself

Abstract

The morphological transformation of the pectoral/shoulder girdle is fundamental to the water-to-land transition in vertebrate evolution. Although previous studies have resolved the embryonic origins of tetrapod shoulder girdles, those of fish pectoral girdles remain uncharacterized, creating a gap in the understanding of girdle transformation mechanisms from fish to tetrapods. Here, we identify the embryonic origins of the zebrafish pectoral girdle, including the cleithrum as an ancestral girdle element lost in extant tetrapods. Our combinatorial approach of photoconversion and genetic lineage tracing demonstrates that cleithrum development combines four adjoining embryonic populations. A comparison of these pectoral girdle progenitors with extinct and extant vertebrates highlights that cleithrum loss, indispensable for neck evolution, is associated with the disappearance of its unique developmental environment at the head/trunk interface. Overall, our study establishes an embryological framework for pectoral/shoulder girdle formation and provides evolutionary trajectories from their origin in water to diversification on land.

Indexed as

Animal FinsBiological EvolutionZebrafishAnimalsEmbryo, NonmammalianPhylogenyShoulder

Identifiers

PMID39060278
PMCPMC11282072

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.