ArticleNature communications2024
The RAE1-STOP1-GL2-RHD6 module regulates the ALMT1-dependent aluminum resistance in Arabidopsis.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed.
- Integrated signaling mechanisms governing root hair growth via transcriptional master regulators.The Plant journal : for cell and molecular biology · 2026Review
- Trichoderma crassum WMM-1-7 reshapes the rhizosphere metabolome of Pseudostellaria heterophylla with benefits.BMC plant biology · 2026Article
- Overexpression ofPlants (Basel, Switzerland) · 2026Article
- A novel SlSTOP1-SlHAK5-cytosolic pH feedback loop drives dual adaptation to proton and aluminum toxicity in tomato.Horticulture research · 2025Article
- Identification of the Q-type ZFP gene family in Triticeaes and drought stress expression analysis in common wheat.Genetica · 2025Article
- CaNature communications · 2025Article
- The RAE1-STOP1 module regulates ABA sensitivity in early seedlings of Arabidopsis.BMC plant biology · 2025Article
- The PP2CH- and PBL27-mediated phosphorylation switch of aluminium ion receptor PSKR1/ALR1 controls plant aluminum sensing ability.Nature plants · 2025Article
- Commonalities and Specificities in Wheat (International journal of molecular sciences · 2024Article
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7 authors.
Funding
Abstract
Aluminum (Al) toxicity is one of the major constraints for crop production in acid soils, Al-ACTIVATED MALATE TRANSPORTER1 (ALMT1)-dependent malate exudation from roots is essential for Al resistance in Arabidopsis, in which the C2H2-type transcription factor SENSITIVE TO PROTONRHIZOTOXICITY1 (STOP1) play a critical role. In this study, we reveal that the RAE1-GL2-STOP1-RHD6 protein module regulated the ALMT1-mediated Al resistance. GL2, STOP1 and RHD6 directly target the promoter of ALMT1 to suppress or activate its transcriptional expression, respectively, and mutually influence their action on the promoter of ALMT1 by forming a protein complex. STOP1 mediates the expression of RHD6 and RHD6-regulated root growth inhibition, while GL2 and STOP1 suppress each other's expression at the transcriptional and translational level and regulate Al-inhibited root growth. F-box protein RAE1 degrades RHD6 via the 26S proteasome, leading to suppressed activity of the ALMT1 promoter. RHD6 inhibits the transcriptional expression of RAE1 by directly targeting its promoter. Unlike RHD6, RAE1 promotes the GL2 expression at the protein level and GL2 activates the expression of RAE1 at the transcriptional level by directly targeting its promoter. The study provides insights into the transcriptional regulation of ALMT1, revealing its significance in Al resistance and highlighting the crucial role of the STOP1-associated regulatory networks.
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