Evidence map›Paper›PMID 39060236›Full record

ArticleNature communications2024

AI-guided few-shot inverse design of HDP-mimicking polymers against drug-resistant bacteria.

Tianyu Wu, Min Zhou, Jingcheng Zou, Qi Chen, Feng Qian, Jürgen Kurths, Runhui Liu, Yang Tang

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
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  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tianyu Wu *Key Laboratory of Smart Manufacturing in Energy Chemical Process, East China University of Science and Technology, Shanghai, 200237, China.
Min Zhou *State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China.ORCID 0000-0002-0444-0324
Jingcheng ZouShanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.ORCID 0000-0002-4839-9650
Qi ChenShanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Frontiers Science Center for Materiobiology and Dynamic Chemistry, Key Laboratory for Ultrafine Materials of Ministry of Education, Research Center for Biomedical Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China.
Feng QianKey Laboratory of Smart Manufacturing in Energy Chemical Process, East China University of Science and Technology, Shanghai, 200237, China.
Jürgen KurthsPotsdam Institute for Climate Impact Research (PIK), Potsdam, 14473, Germany.ORCID 0000-0002-5926-4276
Runhui LiuState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, China. rliu@ecust.edu.cn.ORCID 0000-0002-7699-086X
Yang TangKey Laboratory of Smart Manufacturing in Energy Chemical Process, East China University of Science and Technology, Shanghai, 200237, China. yangtang@ecust.edu.cn.ORCID 0000-0002-2750-8029

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) No. 411803875National Natural Science Foundation of China (National Science Foundation of China) No. 22075078National Natural Science Foundation of China (National Science Foundation of China) No. 62233005
6 · The paper itself

Abstract

Host defense peptide (HDP)-mimicking polymers are promising therapeutic alternatives to antibiotics and have large-scale untapped potential. Artificial intelligence (AI) exhibits promising performance on large-scale chemical-content design, however, existing AI methods face difficulties on scarcity data in each family of HDP-mimicking polymers (<10

Indexed as

Anti-Bacterial AgentsArtificial IntelligencePolymersAntimicrobial PeptidesBacteriaDrug DesignDrug Resistance, BacterialMicrobial Sensitivity TestsAnti-Bacterial AgentsAntimicrobial PeptidesPolymers

Identifiers

PMID39060236
PMCPMC11282099

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.