Evidence map›Paper›PMID 39060143›Full record

ArticleBrachytherapy

Comparison of perioperative and subacute postoperative complications between LDR and HDR monotherapy brachytherapy for prostate cancer.

Peter L Lee, Karen Ruth, Douglas Y Lee, Mark A Hallman, David Y T Chen, Jessica Karen Wong, Andres F Correa, Iavor Veltchev, Teh Lin, Xiaoming Chen and 3 more

Abstract readComparative Study
In one paragraph

Article in Brachytherapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Peter L LeeDepartment of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA. Electronic address: peter.lee@fccc.edu.
Karen RuthBiostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, PA.
Douglas Y LeeDepartment of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA.
Mark A HallmanDepartment of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA.
David Y T ChenDepartment of Urology, Fox Chase Cancer Center, Philadelphia, PA.
Jessica Karen WongDepartment of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA.
Andres F CorreaDepartment of Urology, Fox Chase Cancer Center, Philadelphia, PA.
Iavor VeltchevDepartment of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA.
Teh LinDepartment of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA.
Xiaoming ChenDepartment of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA.
Joseph PanettaDepartment of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA.
Alexander KutikovDepartment of Urology, Fox Chase Cancer Center, Philadelphia, PA.
Eric M HorwitzDepartment of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, PA.

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Eric Andrew Ross · 1985 to 2026
$138.8M
NCI NIH HHS P30 CA006927
6 · The paper itself

Abstract

purposeWe aim to investigate perioperative and subacute postoperative complications in patients undergoing LDR or HDR monotherapy for prostate cancer. We hypothesize a low rate of complications, and a favorable toxicity profile in patients treated with HDR compared to LDR. MATERIALS AND

methodsA prospectively collected institutional database was queried for patients treated with HDR or LDR prostate monotherapy between 1998 and 2021. Toxicities were determined per CTCAE. Claims based billing codes were obtained to identify additional events. Events occurring within 4 months of treatment were defined as perioperative or subacute postoperative complications.

results759 patients were identified, 446 received LDR with

conclusionsOverall toxicity rates support the safety of prostate brachytherapy. HDR monotherapy is associated with significantly less perioperative and subacute postoperative GU events when compared to LDR monotherapy. Cardiopulmonary events were equally rare in both groups.

Indexed as

BrachytherapyPostoperative ComplicationsProstatic NeoplasmsAgedHumansIodine RadioisotopesMaleMiddle AgedProspective StudiesIodine-125Iodine RadioisotopesAcute toxicityBrachytherapyCardiopulmonary toxicityHigh dose rateInterstitialLow dose rateProstate cancerSubacute toxicity

Identifiers

PMID39060143
PMCPMC11426183

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.