Evidence map›Paper›PMID 39059708›Full record

ArticleThe American journal of clinical nutrition2024

Consumption of different combinations of human milk oligosaccharides in the first 6 mo of infancy is positively associated with early cognition at 2 y of age in a longitudinal cohort of Latino children.

Jonatan Ottino-González, Shana Adise, Christopher J Machle, Pari Mokhtari, Elizabeth A Holzhausen, Annalee Furst, Chloe Yonemitsu, Tanya L Alderete, Lars Bode, Bradley S Peterson and 1 more

Abstract read
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In one paragraph

Article in The American journal of clinical nutrition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jonatan Ottino-GonzálezDivision of Endocrinology, Diabetes, and Metabolism, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Shana AdiseDivision of Endocrinology, Diabetes, and Metabolism, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Christopher J MachleDivision of Endocrinology, Diabetes, and Metabolism, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States; Department of Psychology, University of Oregon, Eugene, OR, United States.
Pari MokhtariDivision of Endocrinology, Diabetes, and Metabolism, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States.
Elizabeth A HolzhausenDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States; Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO, United States.
Annalee FurstDepartment of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), and the Human Milk Institute (HMI), University of California, San Diego, CA, United States.
Chloe YonemitsuDepartment of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), and the Human Milk Institute (HMI), University of California, San Diego, CA, United States.
Tanya L AldereteDepartment of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States.
Lars BodeDepartment of Pediatrics, Larsson-Rosenquist Foundation Mother-Milk-Infant Center of Research Excellence (MOMI CORE), and the Human Milk Institute (HMI), University of California, San Diego, CA, United States.
Bradley S PetersonDivision of Endocrinology, Diabetes, and Metabolism, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States; Department of Psychiatry and Behavioral Sciences, Keck School of Medicine at the University of Southern California, Los Angeles, CA, United States.
Michael I GoranDivision of Endocrinology, Diabetes, and Metabolism, Department of Pediatrics, Children's Hospital Los Angeles, Los Angeles, CA, United States. Electronic address: goran@usc.edu.

Funding

Southern California Center for Chronic Health Disparities in Latino Children and Families.P50MD017344 · NIMHD · CHILDREN'S HOSPITAL OF LOS ANGELES · PI BOUTELLE, KERRI N · 2021 to 2025
$27.8M
Impact of Sugars and Human Milk Oligosaccharides on Infant Microbiome and ObesityR01DK110793 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GORAN, MICHAEL ISAAC, PETERSON, BRADLEY S · 2017 to 2024
$6.0M
Brain-Imaging Markers of Neurotoxicity and Long-Term Outcomes after CAR-T Cell TherapyR01CA274137 · NCI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Ravi Bansal, Deepa Bhojwani · 2023 to 2026
$2.8M
Perfluoroalkyl Substances and the Gut Microbiome and Fecal Metabolome: Implications for Obesity Risk in Hispanic ChildrenR01ES035035 · NIEHS · UNIVERSITY OF COLORADO · PI Tanya Lynn Alderete · 2023 to 2026
$2.6M
Neurodevelopment of executive function, appetite regulation, and obesity in children and adolescentsK01DK135847 · NIDDK · UNIVERSITY OF GEORGIA · PI Shana Adise · 2023 to 2026
$603k
NCI NIH HHS R01 CA274137NIDDK NIH HHS K01 DK135847NIDDK NIH HHS R01 DK110793NIEHS NIH HHS R01 ES035035NIMHD NIH HHS P50 MD017344
6 · The paper itself

Abstract

backgroundLactation has been widely associated with optimal neurocognitive development, but the underlying mechanism remains unknown. Human milk oligosaccharides (HMOs) are complex sugars that support brain development, but previous studies examining their associations with cognition have yielded inconsistent findings.

objectivesThis study aimed to provide a broader understanding of how HMOs jointly influence cognition.

methodsWe used data from an ongoing longitudinal cohort of Latino mother-infant dyads. Human milk samples from 1 mo (n = 157) and 6 mo (n = 107) postpartum were assessed for the 19 most abundant HMOs. Cognitive performance was assessed at 2 y using the Bayley Scale of Infant and Toddler Development. A partial least squares model identified HMO combinations predictive of cognitive scores.

resultsAt 1 mo, the combination of higher concentrations of lacto-N-neotetraose (LNnT), lacto-N-tetraose (LNT), lacto-N-fucopentaose (LNFP)-III, 6'-sialyllactose, and 2'-fucosyllactose (FL) with lower concentrations of sialyllacto-N-tetraose (LST) b, LNFP-II, fucodisialyllacto-N-hexaose, and 3-FL significantly predicted higher cognitive scores (β: 0.61; 95% confidence interval [CI]: 0.30, 0.92), explaining an additional 8% of the variance over a model with only nuisance covariates (11%). Additional analyses revealed that the combination of higher LNFP-III and lower LSTb alone explained 5% more of the variation in cognitive scores (β: 0.66; 95% CI: 0.24, 1.09). At 6 mo (n = 107), higher LNnT, LNT, and LNFP-III and lower 3FL and LSTb concentrations explained an extra 6% of the variance in cognitive scores (β: 0.43; 95% CI: 0.12, 0.75).

conclusionsThis study highlights specific HMO combinations in early life influencing cognitive performance at 2 y.

Indexed as

CognitionHispanic or LatinoMilk, HumanOligosaccharidesAdultChild DevelopmentChild, PreschoolCohort StudiesFemaleHumansInfantInfant, NewbornInfant Nutritional Physiological PhenomenaLongitudinal StudiesMaleOligosaccharidesbraincognitioninfantlactationoligosaccharides

Identifiers

PMID39059708
PMCPMC11393400

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.