ArticleEBioMedicine2024
Blood pressure response index and clinical outcomes in patients with septic shock: a multicenter cohort study.
Article in EBioMedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Hemodynamic trajectory phenotypes may modify associations between corticosteroid timing and outcomes in septic shock.Journal of clinical monitoring and computing · 2026Article
- Cardiac index modifies the association between blood pressure response index and 28-day mortality in sepsis.Critical care (London, England) · 2026Article
- Article
- Blood pressure response index trajectories identify distinct hemodynamic phenotypes and predict mortality in septic shock: a two-database retrospective cohort study.Critical care (London, England) · 2026Article
- Establishing a nomogram of the risk of in-hospital mortality in children with suspected sepsis and validating the applicability of the Phoenix.BMC pediatrics · 2026Article
- Predicting 28-day and 90-day mortality in microbiologically-confirmed sepsis: a retrospective cohort study.BMC infectious diseases · 2026Article
- Association between blood pressure response index and in-hospital outcomes in cardiac arrest patients: A retrospective study.Medicine · 2026Article
- Group-based trajectory modeling of blood pressure reactivity and mortality in septic patients: a retrospective study of the MIMIC-IV database.BMC infectious diseases · 2026Article
- Machine Learning Algorithms to Predict Venous Thromboembolism in Patients With Sepsis in the Intensive Care Unit: Multicenter Retrospective Study.JMIR medical informatics · 2026Article
- Interpretable machine learning models using early dynamic clinical features to predict early hemodynamic stabilization after vasopressor initiation in patients with septic shock: development in MIMIC-IV and external validation in eICU.Frontiers in medicine · 2026Article
- Blood pressure response index and acute kidney injury progression in heart failure patients: a retrospective cohort study from MIMIC-IV.BMC nephrology · 2025Article
- Clinical characteristics associated with septic shock complicating hypothermia: a retrospective cohort study from the MIMIC-IV database.European journal of medical research · 2025Article
- Early blood pressure response index and mortality risk in cardiogenic shock: evidence from two critical care cohorts.BMC cardiovascular disorders · 2025Article
- Beta blockers linked to reduced 1-Year mortality in critically ill congestive heart failure patients with differential benefits across subgroups.Scientific reports · 2025Article
- Blood Pressure Response Index and Mortality in Patients With Cardiogenic Shock: A Multicenter Retrospective Cohort Study.Journal of the American Heart Association · 2025Article
- Article
- Construction and validation of nomogram prediction model for clinical efficacy of high-dose continuous renal replacement therapy in sepsis patients based on inflammatory response and microcirculation.Frontiers in medicine · 2025Article
- The U-Shaped Relationship Between Serum Bicarbonate Levels and 28-Day Mortality in Patients With Sepsis: A Retrospective Cohort Study of MIMIC-IV Database.Dose-response : a publication of International Hormesis SocietyArticle
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22 authors.
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Abstract
backgroundSepsis is a leading cause of mortality in intensive care units and vasoactive drugs are widely used in septic patients. The cardiovascular response of septic shock patients during resuscitation therapies and the relationship of the cardiovascular response and clinical outcome has not been clearly described.
methodsWe included adult patients admitted to the ICU with sepsis from Peking Union Medical College Hospital (internal), Medical Information Mart for Intensive Care IV (MIMIC-IV) and eICU Collaborative Research Database (eICU-CRD). The Blood Pressure Response Index (BPRI) was defined as the ratio between the mean arterial pressure and the vasoactive-inotropic score. BRRI was compared with existing risk scores on predicting in-hospital death. The relationship between BPRI and in-hospital mortality was calculated. A XGBoost's machine learning model identified the features that influence short-term changes in BPRI.
findingsThere were 2139, 9455, and 4202 patients in the internal, MIMIC-IV and eICU-CRD cohorts, respectively. BPRI had a better AUROC for predicting in-hospital mortality than SOFA (0.78 vs. 0.73, p = 0.01) and APS (0.78 vs. 0.74, p = 0.03) in the internal cohort. The estimated odds ratio for death per unit decrease in BPRI was 1.32 (95% CI 1.20-1.45) when BPRI was below 7.1 vs. 0.99 (95% CI 0.97-1.01) when BPRI was above 7.1 in the internal cohort; similar relationships were found in MIMIC-IV and eICU-CRD. Respiratory support and latest cumulative 12-h fluid balance were intervention-related features influencing BPRI.
interpretationBPRI is an easy, rapid, precise indicator of the response of patients with septic shock to vasoactive drugs. It is a comparable and even better predictor of prognosis than SOFA and APS in sepsis and it is simpler and more convenient in use. The application of BPRI could help clinicians identify potentially at-risk patients and provide clues for treatment.
fundingFundings for the Beijing Municipal Natural Science Foundation; the National High Level Hospital Clinical Research Funding; the CAMS Innovation Fund for Medical Sciences (CIFMS) from Chinese Academy of Medical Sciences and the National Key R&D Program of China, Ministry of Science and Technology of the People's Republic of China.
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