Evidence map›Paper›PMID 39059240›Full record

ArticleMedical image analysis2024

Generating multi-pathological and multi-modal images and labels for brain MRI.

Virginia Fernandez, Walter Hugo Lopez Pinaya, Pedro Borges, Mark S Graham, Petru-Daniel Tudosiu, Tom Vercauteren, M Jorge Cardoso

Abstract read
In one paragraph

Article in Medical image analysis, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Generating Novel Brain Morphology by Deforming Learned Templates.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Virginia FernandezDepartment of Biomedical Engineering and Imaging Sciences, King's College London, Strand, London, WC2R 2LS, United Kingdom. Electronic address: virginia.fernandez@kcl.ac.uk.
Walter Hugo Lopez PinayaDepartment of Biomedical Engineering and Imaging Sciences, King's College London, Strand, London, WC2R 2LS, United Kingdom.
Pedro BorgesDepartment of Biomedical Engineering and Imaging Sciences, King's College London, Strand, London, WC2R 2LS, United Kingdom.
Mark S GrahamDepartment of Biomedical Engineering and Imaging Sciences, King's College London, Strand, London, WC2R 2LS, United Kingdom.
Petru-Daniel TudosiuDepartment of Biomedical Engineering and Imaging Sciences, King's College London, Strand, London, WC2R 2LS, United Kingdom.
Tom VercauterenDepartment of Biomedical Engineering and Imaging Sciences, King's College London, Strand, London, WC2R 2LS, United Kingdom.
M Jorge CardosoDepartment of Biomedical Engineering and Imaging Sciences, King's College London, Strand, London, WC2R 2LS, United Kingdom.

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
THE XNAT IMAGING INFORMATICS PLATFORMR01EB009352 · NIBIB · WASHINGTON UNIVERSITY · PI Daniel Scott Marcus · 2009 to 2026
$9.3M
DRIVING PERFORMANCE IN PRECLINICAL ALZHEIMER'S DISEASER01AG043434 · NIA · WASHINGTON UNIVERSITY · PI ROE, CATHERINE M · 2012 to 2016
$2.4M
NCATS NIH HHS UL1 TR000448NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS R01 AG043434NIA NIH HHS U01 AG024904NIBIB NIH HHS R01 EB009352Wellcome Trust
6 · The paper itself

Abstract

The last few years have seen a boom in using generative models to augment real datasets, as synthetic data can effectively model real data distributions and provide privacy-preserving, shareable datasets that can be used to train deep learning models. However, most of these methods are 2D and provide synthetic datasets that come, at most, with categorical annotations. The generation of paired images and segmentation samples that can be used in downstream, supervised segmentation tasks remains fairly uncharted territory. This work proposes a two-stage generative model capable of producing 2D and 3D semantic label maps and corresponding multi-modal images. We use a latent diffusion model for label synthesis and a VAE-GAN for semantic image synthesis. Synthetic datasets provided by this model are shown to work in a wide variety of segmentation tasks, supporting small, real datasets or fully replacing them while maintaining good performance. We also demonstrate its ability to improve downstream performance on out-of-distribution data.

Indexed as

Magnetic Resonance ImagingAlgorithmsBrainDeep LearningHumansImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedImaging, Three-DimensionalMultimodal ImagingBrain MRIGenerative modellingMedical imaging segmentation

Identifiers

PMID39059240
PMCPMC11832365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.