Evidence map›Paper›PMID 39058785›Full record

ArticleScience advances2024

Distinct sequential death complexes regulate pyroptosis and IL-1β release in response to

Ronit Schwartz Wertman, Winslow Yost, Beatrice I Herrmann, Christopher M Bourne, Daniel Sorobetea, Christina K Go, Benedikt S Saller, Olaf Groß, Phillip Scott, Anthony Rongvaux and 2 more

Abstract read
In one paragraph

Article in Science advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Caspase-1 in cancer and inflammatory diseases: a potential therapeutic target.Apoptosis : an international journal on programmed cell death · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ronit Schwartz WertmanDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0003-4297-3495
Winslow YostDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.
Beatrice I HerrmannDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0002-2508-9043
Christopher M BourneDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-9290-4223
Daniel SorobeteaDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.
Christina K GoDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0002-7716-8720
Benedikt S SallerInstitute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.ORCID 0000-0003-0790-2720
Olaf GroßInstitute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg 79106, Germany.ORCID 0000-0001-8660-3619
Phillip ScottDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0001-8732-0653
Anthony RongvauxTranslational Science and Therapeutics Division, Fred Hutchinson Cancer Center, Seattle, WA 98109, USA.ORCID 0000-0001-7142-6533
Cornelius Y TaabazuingDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0003-2361-5457
Igor E BrodskyDepartment of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0001-7970-872X

Funding

Defining the mechanism and functions of RIPK1-induced cell death in anti-bacterial immune defenseR01AI139102 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E · 2019 to 2023
$2.8M
Defining the non-apoptotic role of Caspase-8 activity in anti-bacterial immune defenseR01AI128530 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI BRODSKY, IGOR E · 2017 to 2021
$2.0M
Investigating the function of ZU5 domain-containing proteins as amplifiers of caspase activationR00AI148598 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI TAABAZUING, CORNELIUS · 2022 to 2024
$740k
Defining mechanisms of heterogeneity in cell fate decisions during Yersinia pseudotuberculosis infectionF31AI172200 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SCHWARTZ WERTMAN, RONIT · 2022 to 2024
$104k
NIAID NIH HHS F31 AI172200NIAID NIH HHS R00 AI148598NIAID NIH HHS R01 AI128530NIAID NIH HHS R01 AI139102
6 · The paper itself

Abstract

Pathogen infection of host cells triggers an inflammatory cell death termed pyroptosis via activation of inflammatory caspases. However, blockade of immune signaling kinases by the

Indexed as

Caspase 1Caspase 8InflammasomesInterleukin-1betaPhosphate-Binding ProteinsPyroptosisSignal TransductionYersiniaAnimalsBacterial ProteinsGasderminsHumansIntracellular Signaling Peptides and ProteinsMiceYersinia InfectionsBacterial ProteinsCaspase 1Caspase 8GasderminsGsdmd protein, mouseInflammasomesInterleukin-1betaIntracellular Signaling Peptides and ProteinsPhosphate-Binding ProteinsYopP protein, Yersinia

Identifiers

PMID39058785
PMCPMC11277400

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.