Evidence map›Paper›PMID 39058701›Full record

ArticleThe Journal of physiology2024

Central α

Stephen A Klassen, Jacqueline K Limberg, Ronée E Harvey, Chad C Wiggins, Nathaniel J Iannarelli, Jonathon W Senefeld, Wayne T Nicholson, Timothy B Curry, Michael J Joyner, J Kevin Shoemaker and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Transdermal Clonidine for Hypertension: An Underutilized Ally in the Modern Era.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026
    Review
  4. Vasomotion in Human Fingers.Journal of vascular research · 2026
    Article
  5. The role of αAmerican journal of physiology. Heart and circulatory physiology · 2025
    Article
  6. Human sympathetic neuronal discharge and recruitment patterns regulate neuropeptide Y bioavailability.American journal of physiology. Heart and circulatory physiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stephen A KlassenSympathetic Neurocirculatory Regulation Laboratory, Department of Kinesiology, Brock University, St Catharines, ON, Canada.
Jacqueline K LimbergDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, MO, USA.
Ronée E HarveyDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Chad C WigginsDepartment of Kinesiology, Michigan State University, East Lansing, MI, USA.
Nathaniel J IannarelliSympathetic Neurocirculatory Regulation Laboratory, Department of Kinesiology, Brock University, St Catharines, ON, Canada.
Jonathon W SenefeldDepartment of Health and Kinesiology, Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, University of Illinois at Urbana-Champaign, Champaign, IL, USA.
Wayne T NicholsonDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Timothy B CurryDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
Michael J JoynerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.
J Kevin ShoemakerSchool of Kinesiology, Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada.
Sarah E BakerDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, MN, USA.

Funding

DIABETES AND METABOLISMT32DK007352 · NIDDK · MAYO CLINIC ROCHESTER · PI MICHAEL D. JENSEN · 1986 to 2026
$9.4M
Variant Hemoglobin and Cardiorespiratory Regulation in HumansR35HL139854 · NHLBI · MAYO CLINIC ROCHESTER · PI JOYNER, MICHAEL J · 2018 to 2024
$5.8M
Hot Flashes and Neurovascular Function in WomenK01HL148144 · NHLBI · MAYO CLINIC ROCHESTER · PI BAKER, SARAH ELIZABETH · 2021 to 2025
$867k
Skeletal muscle performance and cellular adaptations to high hemoglobin-oxygen affinityF32HL154320 · NHLBI · MAYO CLINIC ROCHESTER · PI SENEFELD, JONATHON · 2020 to 2021
$117k
NHLBI NIH HHS F32 HL154320NHLBI NIH HHS K01 HL148144NHLBI NIH HHS R35 HL139854NIDDK NIH HHS T32 DK007352
6 · The paper itself

Abstract

The present study investigated the impact of central α

Indexed as

Action PotentialsAdrenergic alpha-2 Receptor AgonistsDexmedetomidineSympathetic Nervous SystemAdultBlood PressureFemaleHeart RateHumansMaleMuscle, SkeletalReceptors, Adrenergic, alpha-2Young AdultAdrenergic alpha-2 Receptor AgonistsDexmedetomidineReceptors, Adrenergic, alpha-2action potentialdexmedetomidinehumanmicroneurographymuscle sympathetic nerve activityvalsalva manoeuvreα2‐adrenergic receptors

Identifiers

PMID39058701
PMCPMC11326960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.