Evidence map›Paper›PMID 39058440›Full record

ArticleCancer biomarkers : section A of Disease markers2025

A computed tomography-based score indicative of lung cancer aggression (SILA) predicts lung adenocarcinomas with low malignant potential or vascular invasion.

Dylan Steiner, Ju Ae Park, Sarah Singh, Austin Potter, Jonathan Scalera, Jennifer Beane, Kei Suzuki, Marc E Lenburg, Eric J Burks

Abstract read
In one paragraph

Article in Cancer biomarkers : section A of Disease markers, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dylan SteinerDepartment of Medicine, Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, USA.
Ju Ae ParkThoracic Surgery, Inova Schar Cancer Institute, Fairfax, VA, USA.
Sarah SinghDepartment of Radiology, Boston University Chobanian and Avedisian School of Medicine, Boston, USA.
Austin PotterDepartment of Medicine, Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, USA.
Jonathan ScaleraDepartment of Radiology, Boston University Chobanian and Avedisian School of Medicine, Boston, USA.
Jennifer BeaneDepartment of Medicine, Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, USA.
Kei SuzukiThoracic Surgery, Inova Schar Cancer Institute, Fairfax, VA, USA.
Marc E LenburgDepartment of Medicine, Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, USA.
Eric J BurksDepartment of Pathology, Boston University Chobanian and Avedisian School of Medicine, Boston, USA.

Funding

The Boston University - UCLA Lung Cancer Biomarker Characterization CenterU2CCA271898 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MICHAEL J PALAZZOLO · 2022 to 2026
$5.5M
Integrating imaging and biopsy-derived molecular markers for the pre-surgical detection of indolent and aggressive early stage lung adenocarcinomaR01CA275015 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Marc Elliott Lenburg, Fabien Maldonado · 2023 to 2026
$2.6M
NCI NIH HHS R01 CA275015NCI NIH HHS U2C CA271898
6 · The paper itself

Abstract

BackgroundHistologic grading of lung adenocarcinoma (LUAD) is predictive of outcome but is only possible after surgical resection. A radiomic biomarker predictive of grade has the potential to improve preoperative management of early-stage LUAD.ObjectiveValidate a prognostic radiomic score indicative of lung cancer aggression (SILA) in surgically resected stage I LUAD (

Indexed as

Adenocarcinoma of LungLung NeoplasmsAgedFemaleHumansMaleMiddle AgedNeoplasm InvasivenessPrognosisTomography, X-Ray Computedindolent lung cancerLung adenocarcinomaradiomic biomarkersSILAvascular invasion

Identifiers

PMID39058440
PMCPMC12226792

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.