Evidence map›Paper›PMID 39058327›Full record

ArticleJournal of diabetes investigation2024

Young-onset type 2 diabetes mellitus enhances proteinuria, but not glomerular filtration rate decline: A Japanese cohort study.

Haruka Saito, Hayato Tanabe, Hiroyuki Hirai, Moritake Higa, Kenichi Tanaka, Satoshi Yamaguchi, Gulinu Maimaituxun, Hiroaki Masuzaki, Junichiro J Kazama, Michio Shimabukuro

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes investigation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Haruka SaitoDepartment of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan.
Hayato TanabeDepartment of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan.
Hiroyuki HiraiDepartment of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan.ORCID https://orcid.org/0000-0001-5325-3827
Moritake HigaDepartment of Diabetes and Lifestyle-Related Disease Center, Tomishiro Central Hospital, Okinawa, Japan.
Kenichi TanakaDepartment of Nephrology and Hypertension, Fukushima Medical University School of Medicine, Fukushima, Japan.ORCID https://orcid.org/0000-0003-4655-9355
Satoshi YamaguchiDepartment of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan.
Gulinu MaimaituxunDepartment of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan.
Hiroaki MasuzakiDivision of Endocrinology, Diabetes and Metabolism, Hematology, Rheumatology (Second Department of Internal Medicine), University of the Ryukyus, Okinawa, Japan.ORCID https://orcid.org/0000-0002-2445-1047
Junichiro J KazamaDepartment of Nephrology and Hypertension, Fukushima Medical University School of Medicine, Fukushima, Japan.
Michio ShimabukuroDepartment of Diabetes, Endocrinology, and Metabolism, Fukushima Medical University School of Medicine, Fukushima, Japan.ORCID https://orcid.org/0000-0001-7835-7665

Funding

Japan Society for the Promotion of Science (JPSP) JP16K01823Japan Society for the Promotion of Science (JPSP) JP17K00924The Agency for Medical Research and Development (AMED) 965304
6 · The paper itself

Abstract

AIMS/

introductionThe time course of chronic kidney disease in young-onset type 2 diabetes mellitus remains unclear. We compared the trajectories of proteinuria and estimated glomerular filtration rate (eGFR) decline between young-onset (aged ≤40 years) and late-onset (aged >40 years) type 2 diabetes mellitus in a Japanese multicenter cohort. MATERIALS AND

methodsParticipants without diabetic kidney disease were divided into two groups according to age at diagnosis: young- and late-onset. The primary endpoint was eGFR <60 mL/min/1.73 m

resultsAmong 626 participants with type 2 diabetes mellitus, 78 (12.4%) had young-onset and 548 (87.6%) had late-onset diabetes. The incidence of eGFR <60 mL/min/1.73 m

conclusionsYoung-onset type 2 diabetes mellitus has a lower HR of eGFR <60 mL/min/1.73 m

Indexed as

Age of OnsetDiabetes Mellitus, Type 2Glomerular Filtration RateProteinuriaAdultCohort StudiesDiabetic NephropathiesDisease ProgressionEast Asian PeopleFemaleFollow-Up StudiesHumansIncidenceJapanMaleMiddle AgedDiabetic kidney diseaseProteinuriaYoung‐onset diabetes

Identifiers

PMID39058327
PMCPMC11442850

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.