Evidence map›Paper›PMID 39058180›Full record

ArticleToxics2024

Refined Cumulative Risk Assessment of Pb, Cd, and as in TCM Decoction Based on Bioavailability through In Vitro Digestion/MDCK Cells.

Tiantian Zuo, Feiya Luo, Yaqiong Suo, Yan Chang, Zhao Wang, Hongyu Jin, Jiandong Yu, Shuxia Xing, Yuansheng Guo, Dandan Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Tiantian ZuoNational Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.
Feiya LuoNational Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.
Yaqiong SuoNational Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.
Yan ChangNational Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.
Zhao WangNational Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.ORCID 0000-0002-5161-0971
Hongyu JinNational Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.
Jiandong YuNational Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.
Shuxia XingNational Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.
Yuansheng GuoNational Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.
Dandan WangNational Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.
Feng WeiNational Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.ORCID 0000-0002-7598-0723
Gangli WangNational Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.
Lei SunNational Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.
Shuangcheng MaNational Key Laboratory of Drug Regulatory Science, National Institutes for Food and Drug Control, Beijing 100050, China.

Funding

Key Technology by National Institutes for Food and Drug Control GJJS-2022-7-1The Improvement of Standards by the Chinese Pharmacopoeia Commission 2023Z07
6 · The paper itself

Abstract

In this study, the oral bioavailability of Pb, Cd, and As in three types of traditional Chinese medicines (TCMs) and TCM decoctions were investigated through in vitro PBET digestion/MDKC cell model. Furthermore, a novel cumulative risk assessment model associated with co-exposure of heavy metal(loid)s in TCM and TCM decoction based on bioavailability was developed using hazard index (HI) for rapid screening and target organ toxicity dose modification of the HI (TTD) method for precise assessment. The results revealed that the bioavailability of Pb, Cd, and As in three types of TCM and TCM decoction was 5.32-72.49% and 4.98-51.97%, respectively. After rapid screening of the co-exposure health risks of heavy metal(loid)s by the HI method, cumulative risk assessment results acquired by TTD method based on total metal contents in TCMs indicated that potential health risks associated with the co-exposure of Pb, Cd, and As in

Indexed as

bioavailabilitycumulative risk assessmentdecoctionheavy metal(loid)sin vitro digestion/MDCK celltraditional Chinese medicines

Identifiers

PMID39058180
PMCPMC11281054

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.