Evidence map›Paper›PMID 39058166›Full record

ArticleToxics2024

Endocrine-Disrupting Chemicals Exposure and Neurocognitive Function in the General Population: A Community-Based Study.

Feng-Chieh Su, Yi-Chia Wei, Chiao-Yin Sun, Heng-Jung Hsu, Chin-Chan Lee, Yih-Ting Chen, Heng-Chih Pan, Cheng-Kai Hsu, Yun-An Liu, Chun-Yu Chen

Abstract read
In one paragraph

Article in Toxics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Feng-Chieh SuDepartment of Neurology, Chang Gung Memorial Hospital, Keelung 204, Taiwan.
Yi-Chia WeiDepartment of Neurology, Chang Gung Memorial Hospital, Keelung 204, Taiwan.ORCID 0000-0001-6085-3134
Chiao-Yin SunCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Heng-Jung HsuCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0002-6283-6239
Chin-Chan LeeCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Yih-Ting ChenCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Heng-Chih PanCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Cheng-Kai HsuCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0002-6812-526X
Yun-An LiuCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Chun-Yu ChenCollege of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0001-6054-1974

Funding

Chang Gung Memorial Hospital CRRPG2H0132, CRRPG2H0133, CRRPG2H0134 and CLRPG2L0053
6 · The paper itself

Abstract

backgroundEndocrine-disrupting chemicals (EDCs) are pervasive in everyday environments. The impacts of these chemicals, along with EDC-related lifestyle and dietary habits on neurocognitive function, are not well understood.

methodsThe Chang Gung Community Medicine Research Center conducted a cross-sectional study involving 887 participants. From this initial cohort, 120 individuals were selected based on their EDC exposure scores for detailed analysis. Among these, 67 participants aged 55 years or older were further chosen to undergo cognitive impairment assessments using the Ascertain Dementia-8 (AD-8) questionnaire.

resultsThese 67 older participants did not significantly differ in age, albuminuria, or estimated glomerular filtration rate compared to those with lower impairment scores. This study revealed that mono-(2-ethylhexyl) phthalate (MEHP) levels (8.511 vs. 6.432 µg/g creatinine,

conclusionExposure to EDCs, specifically di-(2-ethylhexyl) phthalate, the precursor to MEHP, may be associated with neurocognitive impairment in middle-aged and older adults.

Indexed as

dementiaendocrine-disrupting chemicalsneurocognitive disorderparabenphenolphthalate

Identifiers

PMID39058166
PMCPMC11281080

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.