Evidence map›Paper›PMID 39058047›Full record

ArticleTomography (Ann Arbor, Mich.)2024

Fat Fraction Extracted from Whole-Body Magnetic Resonance (WB-MR) in Bone Metastatic Prostate Cancer: Intra- and Inter-Reader Agreement of Single-Slice and Volumetric Measurements.

Giorgio Maria Agazzi, Nunzia Di Meo, Paolo Rondi, Chiara Saeli, Alberto Dalla Volta, Marika Vezzoli, Alfredo Berruti, Andrea Borghesi, Roberto Maroldi, Marco Ravanelli and 1 more

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Article in Tomography (Ann Arbor, Mich.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giorgio Maria AgazziNeuroradiology Department, ASST Santi Paolo e Carlo, 20142 Milan, Italy.
Nunzia Di MeoRadiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy.ORCID 0000-0003-2725-0766
Paolo RondiRadiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy.ORCID 0000-0003-4070-1277
Chiara SaeliDepartment of Radiology, University of Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy.
Alberto Dalla VoltaDepartment of Oncology, University of Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy.ORCID 0000-0001-8009-7663
Marika VezzoliDepartment of Molecular and Translational, University of Brescia, Piazza del Mercato 15, 25123 Brescia, Italy.ORCID 0000-0002-0424-4235
Alfredo BerrutiDepartment of Oncology, University of Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy.ORCID 0000-0002-3956-0043
Andrea BorghesiRadiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy.ORCID 0000-0002-4761-2923
Roberto MaroldiRadiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy.ORCID 0000-0001-5664-353X
Marco RavanelliRadiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy.
Davide FarinaRadiology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, P.le Spedali Civili 1, 25123 Brescia, Italy.ORCID 0000-0003-4075-0001

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study evaluates the repeatability and reproducibility of fat-fraction percentage (FF%) in whole-body magnetic resonance imaging (WB-MRI) of prostate cancer patients with bone metastatic hormone naive disease.

methodsPatients were selected from the database of a prospective phase-II trial. The treatment response was assessed using the METastasis Reporting and Data System for Prostate (MET-RADS-P). Two operators identified a Small Active Lesion (SAL, <10 mm) and a Large Active Lesion (LAL, ≥10 mm) per patient, performing manual segmentation of lesion volume and the largest cross-sectional area. Measurements were repeated by one operator after two weeks. Intra- and inter-reader agreements were assessed via Interclass Correlation Coefficient (ICC) on first-order radiomics features.

resultsIntra-reader ICC showed high repeatability for both SAL and LAL in a single slice (SS) and volumetric (VS) measurements with values ranging from 0.897 to 0.971. Inter-reader ICC ranged from 0.641 to 0.883, indicating moderate to good reproducibility. Spearman's rho analysis confirmed a strong correlation between SS and VS measurements for SAL (0.817) and a moderate correlation for LAL (0.649). Both intra- and inter-rater agreement exceeded 0.75 for multiple first-order features across lesion sizes.

conclusionThis study suggests that FF% measurements are reproducible, particularly for larger lesions in both SS and VS assessments.

Indexed as

Bone NeoplasmsMagnetic Resonance ImagingProstatic NeoplasmsWhole Body ImagingAdipose TissueAgedHumansMaleMiddle AgedObserver VariationProspective StudiesReproducibility of Resultsbone metastasisfat fractionMET-RADS-Pprostate cancerradiomicswhole-body magnetic resonance imaging

Identifiers

PMID39058047
PMCPMC11280977

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.