ArticleeLife2024
Cholinergic input to mouse visual cortex signals a movement state and acutely enhances layer 5 responsiveness.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Learning how to experience the world: From circuits to cell types to genes.Current opinion in neurobiology · 2026Review
- Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors.Nature communications · 2026Article
- Pupil-linked arousal heterogeneously modulates cell-type-specific sensory processing.Science advances · 2026Article
- Distinct roles of prefrontal subregion feedback to the primary visual cortex across behavioral states.Neuron · 2026Article
- Cholinergic Dynamics in the Septo-hippocampal System Provide Phasic Multiplexed Signals for Spatial Novelty and Correlate with Behavioral States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Prefrontal Cortex subregions provide distinct visual and behavioral feedback modulation to the Primary Visual Cortex.bioRxiv : the preprint server for biology · 2025Article
- Activity in serotonergic axons in visuomotor areas of cortex is modulated by the recent history of visuomotor coupling.Peer community journal · 2025Article
- Quantification of the effect of hemodynamic occlusion in two-photon imaging of mouse cortex.eLife · 2025Article
- Frontal noradrenergic and cholinergic transients exhibit distinct spatiotemporal dynamics during competitive decision-making.Science advances · 2025Article
- Article
- Cholinergic dynamics in the septo-hippocampal system provide phasic multiplexed signals for spatial novelty and correlate with behavioral states.bioRxiv : the preprint server for biology · 2025Article
- Cortical acetylcholine dynamics are predicted by cholinergic axon activity and behavior state.Cell reports · 2024Article
- Flexible neural population dynamics govern the speed and stability of sensory encoding in mouse visual cortex.Nature communications · 2024Article
- Article
- Cortical acetylcholine dynamics are predicted by cholinergic axon activity and behavior state.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Acetylcholine is released in visual cortex by axonal projections from the basal forebrain. The signals conveyed by these projections and their computational significance are still unclear. Using two-photon calcium imaging in behaving mice, we show that basal forebrain cholinergic axons in the mouse visual cortex provide a binary locomotion state signal. In these axons, we found no evidence of responses to visual stimuli or visuomotor prediction errors. While optogenetic activation of cholinergic axons in visual cortex in isolation did not drive local neuronal activity, when paired with visuomotor stimuli, it resulted in layer-specific increases of neuronal activity. Responses in layer 5 neurons to both top-down and bottom-up inputs were increased in amplitude and decreased in latency, whereas those in layer 2/3 neurons remained unchanged. Using opto- and chemogenetic manipulations of cholinergic activity, we found acetylcholine to underlie the locomotion-associated decorrelation of activity between neurons in both layer 2/3 and layer 5. Our results suggest that acetylcholine augments the responsiveness of layer 5 neurons to inputs from outside of the local network, possibly enabling faster switching between internal representations during locomotion.
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