Evidence map›Paper›PMID 39057501›Full record

ReviewGels (Basel, Switzerland)2024

Stimuli-Responsive Nanocomposite Hydrogels for Oral Diseases.

Raffaele Conte, Anna Valentino, Silvia Romano, Sabrina Margarucci, Orsolina Petillo, Anna Calarco

Abstract readReview
In one paragraph

Review in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Injectable Piezoelectric Hydrogel for Vital Pulp Therapy.Journal of functional biomaterials · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Hydrogels in Oral Disease Management: A Review of Innovations in Drug Delivery and Tissue Regeneration.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Raffaele ConteResearch Institute on Terrestrial Ecosystems (IRET), National Research Council (CNR), Via Pietro Castellino 111, 80131 Naples, Italy.
Anna ValentinoResearch Institute on Terrestrial Ecosystems (IRET), National Research Council (CNR), Via Pietro Castellino 111, 80131 Naples, Italy.ORCID 0000-0001-8041-2221
Silvia RomanoResearch Institute on Terrestrial Ecosystems (IRET), National Research Council (CNR), Via Pietro Castellino 111, 80131 Naples, Italy.
Sabrina MargarucciResearch Institute on Terrestrial Ecosystems (IRET), National Research Council (CNR), Via Pietro Castellino 111, 80131 Naples, Italy.
Orsolina PetilloResearch Institute on Terrestrial Ecosystems (IRET), National Research Council (CNR), Via Pietro Castellino 111, 80131 Naples, Italy.ORCID 0000-0002-4193-6660
Anna CalarcoResearch Institute on Terrestrial Ecosystems (IRET), National Research Council (CNR), Via Pietro Castellino 111, 80131 Naples, Italy.ORCID 0000-0002-1441-7662

Funding

ational Recovery and Resil-ience Plan (NRRP), Mission 4 Component 2 Investment 1.4 - Call for tender No. 3138 of 16 De-cember 2021, rectified by Decree n.3175 of 18 December 2021 of Italian Ministry of University and Research funded by the European Union CN_00000033NextGenerationEU within the framework of National Biodiversity Future Center (NBFC) P2022RZ8WM
6 · The paper itself

Abstract

Oral diseases encompassing conditions such as oral cancer, periodontitis, and endodontic infections pose significant challenges due to the oral cavity's susceptibility to pathogenic bacteria and infectious agents. Saliva, a key component of the oral environment, can compromise drug efficacy during oral disease treatment by diluting drug formulations and reducing drug-site interactions. Thus, it is imperative to develop effective drug delivery methods. Stimuli-responsive nanocomposite hydrogels offer a promising solution by adapting to changes in environmental conditions during disease states, thereby enabling targeted drug delivery. These smart drug delivery systems have the potential to enhance drug efficacy, minimize adverse reactions, reduce administration frequency, and improve patient compliance, thus facilitating a faster recovery. This review explores various types of stimuli-responsive nanocomposite hydrogels tailored for smart drug delivery, with a specific focus on their applications in managing oral diseases.

Indexed as

drug deliveryendodontic infectionsnanocomposite hydrogelsoral cancerperiodontitis

Identifiers

PMID39057501
PMCPMC11275451

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.