Evidence map›Paper›PMID 39057462›Full record

ArticleGels (Basel, Switzerland)2024

Streamlining Skin Regeneration: A Ready-To-Use Silk Bilayer Wound Dressing.

Anabela Veiga, Inês V Silva, Juliana R Dias, Nuno M Alves, Ana L Oliveira, Viviana P Ribeiro

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anabela VeigaUniversidade Católica Portuguesa, CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.ORCID 0000-0002-5677-9629
Inês V SilvaUniversidade Católica Portuguesa, CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.
Juliana R DiasCentre for Rapid and Sustainable Product Development, Instituto Politécnico de Leiria, 2430-028 Marinha Grande, Portugal.ORCID 0000-0002-7079-1069
Nuno M AlvesCentre for Rapid and Sustainable Product Development, Instituto Politécnico de Leiria, 2430-028 Marinha Grande, Portugal.ORCID 0000-0002-5016-0868
Ana L OliveiraUniversidade Católica Portuguesa, CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.ORCID 0000-0001-8012-4203
Viviana P RibeiroUniversidade Católica Portuguesa, CBQF-Centro de Biotecnologia e Química Fina-Laboratório Associado, Escola Superior de Biotecnologia, Rua Diogo Botelho 1327, 4169-005 Porto, Portugal.ORCID 0000-0002-3679-0759

Funding

FCT/MCTES (PIDDAC) LA/P/0045/2020 (ALiCE), UIDB/00511/2020 and UIDP/00511/2020 (LEPABE)Foundation for Science and Technology UIDB/50016/2020IBEROS+ (0072_IBEROS_MAIS_1_E, Interreg-POCTEP 2021-2027)Sustainable Bioeconomy, PRR BE@T-Bioeconomy for Textiles and Apparel, investment TC-C12-i01through FCT (Foundation for Science and Technology) 2020.08683.BD]
6 · The paper itself

Abstract

Silk proteins have been highlighted in the past decade for tissue engineering (TE) and skin regeneration due to their biocompatibility, biodegradability, and exceptional mechanical properties. While silk fibroin (SF) has high structural and mechanical stability with high potential as an external protective layer, traditionally discarded sericin (SS) has shown great potential as a natural-based hydrogel, promoting cell-cell interactions, making it an ideal material for direct wound contact. In this context, the present study proposes a new wound dressing approach by developing an SS/SF bilayer construct for full-thickness exudative wounds. The processing methodology implemented included an innovation element and the cryopreservation of the SS intrinsic secondary structure, followed by rehydration to produce a hydrogel layer, which was integrated with a salt-leached SF scaffold to produce a bilayer structure. In addition, a sterilization protocol was developed using supercritical technology (sCO

Indexed as

bilayersilk fibroinsilk sericinwound dressing

Identifiers

PMID39057462
PMCPMC11276312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.