Evidence map›Paper›PMID 39057059›Full record

ReviewCurrent issues in molecular biology2024

Beyond the Coagulation Cascade: Vitamin K and Its Multifaceted Impact on Human and Domesticated Animal Health.

Rebecka A Sadler, Anna K Shoveller, Umesh K Shandilya, Armen Charchoglyan, Lauraine Wagter-Lesperance, Byram W Bridle, Bonnie A Mallard, Niel A Karrow

Abstract readReview
In one paragraph

Review in Current issues in molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Sex-Related Effect of Chronic Doses of Warfarin and Menadione onInternational journal of molecular sciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rebecka A SadlerDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.
Anna K ShovellerDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0000-0002-2584-4774
Umesh K ShandilyaDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.ORCID 0000-0003-0148-8485
Armen CharchoglyanImmunoCeutica Inc., Cambridge, ON N1T 1N6, Canada.
Lauraine Wagter-LesperanceImmunoCeutica Inc., Cambridge, ON N1T 1N6, Canada.
Byram W BridleImmunoCeutica Inc., Cambridge, ON N1T 1N6, Canada.ORCID 0000-0002-8335-1118
Bonnie A MallardImmunoCeutica Inc., Cambridge, ON N1T 1N6, Canada.
Niel A KarrowDepartment of Animal Biosciences, University of Guelph, Guelph, ON N1G 2W1, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin K (VK) is an essential micronutrient impacting many systems in the body. This lipid-soluble vitamin is found in various plant and animal products and is absorbed via the lymphatic system. This biomolecule's importance to human health includes but is not limited to its promotion of brain, cardiovascular, bone, and immune functions. These biological properties are also necessary for maintaining domesticated animal health. The synergistic impact of both VK and vitamin D (VD) maximizes these health benefits, specifically for the circulatory and skeletal systems. This manuscript reviews VK's properties, molecular structures, nutrikinetics, mechanisms of action, daily requirements, safety in supplemental form, biomarkers used for its detection, and impacts on various organs. The purpose of synthesizing this information is to evaluate the potential uses of VK for the treatment or prevention of diseases.

Indexed as

anti-inflammationapoptosiscoagulationimmunomodulationmicrobiotaMK-4MK-7neuroprotectionphylloquinonevitamin K

Identifiers

PMID39057059
PMCPMC11276079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.