Evidence map›Paper›PMID 39056799›Full record

ArticleCells2024

Widespread Distribution of Luteinizing Hormone/Choriogonadotropin Receptor in Human Juvenile Angiofibroma: Implications for a Sex-Specific Nasal Tumor.

Silke Wemmert, Martina Pyrski, Lukas Pillong, Maximilian Linxweiler, Frank Zufall, Trese Leinders-Zufall, Bernhard Schick

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Silke WemmertDepartment of Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, 66424 Homburg, Germany.ORCID 0000-0002-7109-5188
Martina PyrskiCenter for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66424 Homburg, Germany.ORCID 0000-0002-5751-178X
Lukas PillongDepartment of Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, 66424 Homburg, Germany.ORCID 0000-0002-9057-7684
Maximilian LinxweilerDepartment of Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, 66424 Homburg, Germany.ORCID 0000-0002-5028-9282
Frank ZufallCenter for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66424 Homburg, Germany.ORCID 0000-0002-4383-8618
Trese Leinders-ZufallCenter for Integrative Physiology and Molecular Medicine (CIPMM), Saarland University, 66424 Homburg, Germany.ORCID 0000-0002-0678-362X
Bernhard SchickDepartment of Otorhinolaryngology, Head and Neck Surgery, Saarland University Medical Center, 66424 Homburg, Germany.

Funding

Deutsche Forschungsgemeinschaft INST 256/427-1 FUGBDeutsche Forschungsgemeinschaft TRR152Else-Kröner-Fresenius-Stiftung 2022EKEA.21
6 · The paper itself

Abstract

Juvenile angiofibroma (JA) is a rare, sex-specific, and highly vascularized nasal tumor that almost exclusively affects male adolescents, but its etiology has been controversial. The G protein-coupled hormone receptor LHCGR [luteinizing hormone (LH)/choriogonadotropin (hCG) receptor] represents a promising new candidate for elucidating the underlying mechanisms of sex specificity, pubertal manifestation, and JA progression. We used highly sensitive RNAscope technology, together with immunohistochemistry, to investigate the cellular expression, localization, and distribution of LHCGR in tissue samples from JA patients. Our results provide evidence for LHCGR expression in subsets of cells throughout JA tissue sections, with the majority of LHCGR

Indexed as

AngiofibromaReceptors, LHAdolescentChildFemaleHumansMaleNerve Tissue ProteinsNose NeoplasmsReceptors, Nerve Growth FactorSex CharacteristicsLHCGR protein, humanNerve Tissue ProteinsNGFR protein, humanReceptors, LHReceptors, Nerve Growth FactorhCGjuvenile angiofibromaLHLHCGRLH/FSH rationasopharyngealRNAscopesex specifictumor

Identifiers

PMID39056799
PMCPMC11274802

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.