Evidence map›Paper›PMID 39056789›Full record

ArticleCells2024

APOE4 Increases Energy Metabolism in APOE-Isogenic iPSC-Derived Neurons.

Vanessa Budny, Yannic Knöpfli, Debora Meier, Kathrin Zürcher, Chantal Bodenmann, Siri L Peter, Terry Müller, Marie Tardy, Cedric Cortijo, Christian Tackenberg

Abstract read
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Lithium chloride suppresses ferroptosis of induced pluripotent stem cells with ApoE4/E4 from a sporadic Alzheimer's disease patient.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  4. Article
  5. Review
  6. Proteomic and metabolic profiling revealsbioRxiv : the preprint server for biology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Experimental Cell Models for Investigating Neurodegenerative Diseases.International journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Vanessa BudnyInstitute for Regenerative Medicine, University of Zurich, 8952 Schlieren, Switzerland.
Yannic KnöpfliInstitute for Regenerative Medicine, University of Zurich, 8952 Schlieren, Switzerland.
Debora MeierInstitute for Regenerative Medicine, University of Zurich, 8952 Schlieren, Switzerland.
Kathrin ZürcherInstitute for Regenerative Medicine, University of Zurich, 8952 Schlieren, Switzerland.
Chantal BodenmannInstitute for Regenerative Medicine, University of Zurich, 8952 Schlieren, Switzerland.
Siri L PeterInstitute for Regenerative Medicine, University of Zurich, 8952 Schlieren, Switzerland.
Terry MüllerNeurimmune AG, Wagistrasse 18, 8952 Schlieren, Switzerland.
Marie TardyNeurimmune AG, Wagistrasse 18, 8952 Schlieren, Switzerland.
Cedric CortijoNeurimmune AG, Wagistrasse 18, 8952 Schlieren, Switzerland.ORCID 0009-0007-2239-0344
Christian TackenbergInstitute for Regenerative Medicine, University of Zurich, 8952 Schlieren, Switzerland.ORCID 0000-0002-0019-3055

Funding

Dr. Wilhelm Hurka Foundation n.a.Hartmann Müller Foundation 2711
6 · The paper itself

Abstract

The apolipoprotein E4 (

Indexed as

Apolipoprotein E4Energy MetabolismInduced Pluripotent Stem CellsMitochondriaNeuronsAdenosine TriphosphateApolipoproteins ECell DifferentiationHumansAdenosine TriphosphateApolipoprotein E4Apolipoproteins EAlzheimer’s diseaseapolipoprotein E (APOE)energy metabolismglycolysishuman neuronsinduced pluripotent stem cells (iPSCs)mitochondriaoxidative phosphorylation (OXPHOS)

Identifiers

PMID39056789
PMCPMC11274733

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.