ReviewCells2024
Selected Functions and Disorders of Mitochondrial Metabolism under Lead Exposure.
Review in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed.
- Molecular Basis of Ferroptosis and Pyroptosis in Lead-Induced Neurotoxicity: A Narrative Review of Current Evidence and Therapeutic Implications.Biological trace element research · 2026Review
- Lead Is Toxic to Neuronal Cells by Inducing Oxidative Stress and Activating Neuroinflammatory Pathways.Brain sciences · 2026Article
- Ginsenoside Rh1 Modulates GABAergic Inhibitory Homeostasis and Mitochondrial Quality Control During Lead (Pb)-Associated Neuronal Dysfunction.Molecules (Basel, Switzerland) · 2026Article
- Promotion of Lead-induced Cytotoxicity in Differentiating Neural Cells and Protective Effects of Selenium.Biological trace element research · 2026Article
- Caffeic Acid Mitigates Behavioral and Biochemical Alterations in Lead-induced Neurotoxicity in Rats With Possible Involvement of TFEB.Neurotoxicity research · 2026Article
- Multi-Element Exposure in a High-Altitude Páramo Mining District and Oxidative Stress Biomarkers in Gold Miners.Toxics · 2026Article
- Article
- Global Burden of Lead Exposure: Integrating Epidemiology, Molecular Mechanisms, and Mitigation Approaches.Health science reports · 2026Article
- Toward Smart Salivary Diagnostics: A Comprehensive Review of Heavy Metal Biomarkers and Digital Risk Modeling.Diagnostics (Basel, Switzerland) · 2026Review
- Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead-Induced Hepatocytes Pyroptosis in Common Carp (Cyprinus carpio L.).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Selenoprotein M Protects Intestinal Health in Nickel-Exposed Mice: Implications for Animal Welfare Under Heavy Metal Stress.Veterinary sciences · 2025Article
- The Mechanisms of Lead Toxicity in Living Organisms.Journal of xenobiotics · 2025Review
- Review
- Lead Induces Mitochondrial Dysregulation in SH-SY5Y Neuroblastoma Cells via a lncRNA/circRNA-miRNA-mRNA Interdependent Networks.International journal of molecular sciences · 2025Article
- Glutamate-Mediated Neural Alterations in Lead Exposure: Mechanisms, Pathways, and Phenotypes.Toxics · 2025Review
- Lead neurotoxicity in experimental models: A systematic review on effects on the cerebrum, cerebellum, and hippocampus.Toxicology reports · 2025Review
- The independent and interactive effects of heavy metal pollution and vitamin D deficiency on early kidney injury indicators: analysis of the National Health and Nutrition Examination Survey 2001-2004.BMC public health · 2025Article
- Novel plasma cytokines identified and validated in children during lead exposure according to the new updated BLRV.Scientific reports · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitochondria play a fundamental role in the energy metabolism of eukaryotic cells. Numerous studies indicate lead (Pb) as a widely occurring environmental factor capable of disrupting oxidative metabolism by modulating the mitochondrial processes. The multitude of known molecular targets of Pb and its strong affinity for biochemical pathways involving divalent metals suggest that it may pose a health threat at any given dose. Changes in the bioenergetics of cells exposed to Pb have been repeatedly demonstrated in research, primarily showing a reduced ability to synthesize ATP. In addition, lead interferes with mitochondrial-mediated processes essential for maintaining homeostasis, such as apoptosis, mitophagy, mitochondrial dynamics, and the inflammatory response. This article describes selected aspects of mitochondrial metabolism in relation to potential mechanisms of energy metabolism disorders induced by Pb.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.