Evidence map›Paper›PMID 39056709›Full record

ArticleBiology2024

Regional Changes in Brain Biomolecular Markers in a Collagen-Induced Arthritis Rat Model.

Aletta M E Millen, Tshiamo T Maluleke, Leandrie Pienaar, Farhanah N Sallie, Radhini Veerappan, Per E Andrén, Sooraj Baijnath

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Aletta M E MillenWits Integrated Molecular Physiology Research Initiative, Wits Health Consortium (PTY) Ltd., University of the Witwatersrand, Johannesburg 2191, South Africa.ORCID 0000-0002-4831-7336
Tshiamo T MalulekeWits Integrated Molecular Physiology Research Initiative, Wits Health Consortium (PTY) Ltd., University of the Witwatersrand, Johannesburg 2191, South Africa.ORCID 0000-0002-7233-3555
Leandrie PienaarWits Integrated Molecular Physiology Research Initiative, Wits Health Consortium (PTY) Ltd., University of the Witwatersrand, Johannesburg 2191, South Africa.
Farhanah N SallieWits Integrated Molecular Physiology Research Initiative, Wits Health Consortium (PTY) Ltd., University of the Witwatersrand, Johannesburg 2191, South Africa.ORCID 0000-0002-8201-921X
Radhini VeerappanWits Integrated Molecular Physiology Research Initiative, Wits Health Consortium (PTY) Ltd., University of the Witwatersrand, Johannesburg 2191, South Africa.
Per E AndrénDepartment of Pharmaceutical Biosciences, Spatial Mass Spectrometry, Science for Life Laboratory, Uppsala University, 75121 Uppsala, Sweden.ORCID 0000-0002-4062-7743
Sooraj BaijnathWits Integrated Molecular Physiology Research Initiative, Wits Health Consortium (PTY) Ltd., University of the Witwatersrand, Johannesburg 2191, South Africa.ORCID 0000-0001-7860-1779

Funding

International Brain Research Organisation N/ASouth African National Research Foundation N/AUniversity of the Witwatersrand N/A
6 · The paper itself

Abstract

backgroundThe effects of collagen-induced arthritis (CIA), a model of systemic inflammation, on brain regional molecular markers associated with neurological disorders are uncertain.

objectiveThis study investigated the brain regional molecular changes in markers associated with inflammation and neuronal dysfunction in a CIA model.

methodsFourteen male Sprague Dawley rats were divided into control (n = 5) or CIA (n = 9) groups. 10 weeks after CIA induction, brain tissue was collected. Brain regional mRNA expression of inflammatory markers (

resultsNeuroinflammation was confirmed in the CIA group by increased

conclusionCIA resulted in neuroinflammation concurrent with an apoptotic state and aberrant expression of neurotrophic factors and monoamines in the brain, suggestive of neurodegeneration.

Indexed as

braincollagen-induced arthritis (CIA)inflammationneuroinflammationneurotransmittersneurotrophic factors

Identifiers

PMID39056709
PMCPMC11273993

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.