ArticleBiosensors2024
An Efficient Bio-Receptor Layer Combined with a Plasmonic Plastic Optical Fiber Probe for Cortisol Detection in Saliva.
Article in Biosensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Periodontal Disease Diagnosis by a Chemically Etched Single-Mode Fiber-Optic Biosensor for Label-Free Detection of Matrix Metalloproteinase-8 (MMP-8).Biosensors · 2026Article
- Nanomaterial-Enabled Fiber-Optic SPR Biosensor for Continuous and Noninvasive Body Fluid Monitoring:Progress and Prospects.Nanomaterials (Basel, Switzerland) · 2026Review
- Flexible ACEK-Enhanced Capacitive Aptasensor for Rapid Cortisol Detection in Sweat.Micromachines · 2026Article
- Molecularly imprinted polypyrrole-based POF dual sensor for dopamine detection exploiting plasmonic and voltammetric methods.iScience · 2025Article
- Salivary Biosensing Opportunities for Predicting Cognitive and Physical Human Performance.Biosensors · 2025Article
- Review
- A Wearable Molecularly Imprinted Electrochemical Sensor for Cortisol Stable Monitoring in Sweat.Biosensors · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
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Abstract
Cortisol is a clinically validated stress biomarker that takes part in many physiological and psychological functions related to the body's response to stress factors. In particular, it has emerged as a pivotal tool for understanding stress levels and overall well-being. Usually, in clinics, cortisol levels are monitored in blood or urine, but significant changes are also registered in sweat and saliva. In this work, a surface plasmon resonance probe based on a D-shaped plastic optical fiber was functionalized with a glucocorticoid receptor exploited as a highly efficient bioreceptor specific to cortisol. The developed plastic optical fiber biosensor was tested for cortisol detection in buffer and artificial saliva. The biosensor response showed very good selectivity towards other hormones and a detection limit of about 59 fM and 96 fM in phosphate saline buffer and artificial saliva, respectively. The obtained detection limit, with a rapid detection time (about 5 min) and a low-cost sensor system, paved the way for determining the cortisol concentration in saliva samples without any extraction process or sample pretreatment via a point-of-care test.
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Registered trials
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