Evidence map›Paper›PMID 39056333›Full record

ArticleJournal of the American Heart Association2024

Cardiovascular Diseases Increase Cancer Mortality in Adults: NHANES-Continuous Study.

Omar M Makram, Tochukwu Okwuosa, Daniel Addison, Jorge Cortes, Susan Dent, Malcolm Bevel, Sarju Ganatra, Sadeer Al-Kindi, Catherine C Hedrick, Neal L Weintraub and 2 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. A Systematic Review of Cardiovascular Health Among Cancer Survivors.International journal of environmental research and public health · 2025
    Pooled it
  4. Pooled it
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Tackling the Cardio-Kidney-Metabolic Burden in Cancer.Current atherosclerosis reports · 2025
    Review
  11. Article
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  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Omar M MakramDepartment of Medicine Medical College of Georgia at Augusta University Augusta GA USA.ORCID 0000-0001-8361-9068
Tochukwu OkwuosaDivision of Cardiology, Department of Internal Medicine Rush University Medical Center Chicago IL USA.ORCID 0000-0001-7666-1217
Daniel AddisonCardio-Oncology Program The Ohio State University Columbus OH USA.ORCID 0000-0002-9113-8333
Jorge CortesGeorgia Cancer Center Augusta University Augusta GA USA.ORCID 0000-0002-8636-1071
Susan DentDuke Cancer Institute Duke University Durham NC USA.ORCID 0000-0002-9183-9340
Malcolm BevelGeorgia Cancer Center Augusta University Augusta GA USA.ORCID 0000-0002-9907-0089
Sarju GanatraDepartment of Cardiology Lahey Hospital and Medical Center, Beth Israel Lahey Health Burlington MA USA.ORCID 0000-0003-0296-6864
Sadeer Al-KindiHouston Methodist DeBakey Heart &Vascular Center Houston TX USA.ORCID 0000-0002-1122-7695
Catherine C HedrickImmunology Center of Georgia Augusta University Augusta GA USA.ORCID 0000-0003-2045-4117
Neal L WeintraubCardio-Oncology Program, Department of Medicine, Cardiology Division Medical College of Georgia at Augusta University Augusta GA USA.ORCID 0000-0002-5138-3705
Xiaoling WangGeorgia Prevention Institute Medical College of Georgia at Augusta University Augusta GA USA.ORCID 0000-0001-9290-7926
Avirup GuhaCardio-Oncology Program, Department of Medicine, Cardiology Division Medical College of Georgia at Augusta University Augusta GA USA.ORCID 0000-0003-0253-1174

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBoth cancer and cardiovascular disease (CVD) are the leading causes of death worldwide. Although our previous study detected a relationship between CVD and cancer incidence, limited evidence is available regarding the relationship between CVD, cardiovascular risk factors, and cancer mortality. METHODS AND

resultsA prospective cohort study using data from the continuous NHANES (National Health and Nutrition Examination Survey, 1999-2016) merged with Medicare and National Death Index mortality data, through December 31, 2018. We included individuals with no history of cancer at baseline. The primary exposure was CVD at baseline. We also conducted a comprehensive risk factor analysis as secondary exposure. The main outcome was cancer mortality data collected from Medicare and National Death Index. We included 44 591 adult individuals representing 1 738 423 317 individuals (52% female, 67% non-Hispanic White, and 9% Hispanic). Competing risk modeling showed a significantly higher risk of cancer mortality in individuals with CVD (adjusted hazard ratio [aHR], 1.37 [95% CI 1.07-1.76],

conclusionsOur study highlights the close relationship between cardiovascular health and cancer mortality. Our findings suggest that obesity may play a significant role in cancer mortality among individuals with CVD. These findings emphasize the need for a more proactive approach in managing the shared risk factors for CVD and cancer.

Indexed as

Cardiovascular DiseasesNeoplasmsNutrition SurveysAdultAgedCause of DeathFemaleHumansIncidenceMaleMiddle AgedProspective StudiesRisk AssessmentRisk FactorsUnited Statescancercardio‐oncologyCVDNHANES

Identifiers

PMID39056333
PMCPMC11964072

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.