Evidence map›Paper›PMID 39056332›Full record

ArticleJournal of the American Heart Association2024

Endothelial Cell-Specific Prolyl Hydroxylase-2 Deficiency Augments Angiotensin II-Induced Arterial Stiffness and Cardiac Pericyte Recruitment in Mice.

Bo Liu, Heng Zeng, Han Su, Quinesha A Williams, Jessie Besanson, Yingjie Chen, Jian-Xiong Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bo LiuDepartment of Pharmacology and Toxicology University of Mississippi Medical Center, School of Medicine Jackson MS.
Heng ZengDepartment of Pharmacology and Toxicology University of Mississippi Medical Center, School of Medicine Jackson MS.ORCID 0000-0001-8559-2807
Han SuDepartment of Pharmacology and Toxicology University of Mississippi Medical Center, School of Medicine Jackson MS.
Quinesha A WilliamsDepartment of Pharmacology and Toxicology University of Mississippi Medical Center, School of Medicine Jackson MS.ORCID 0009-0008-2432-6861
Jessie BesansonDepartment of Pharmacology and Toxicology University of Mississippi Medical Center, School of Medicine Jackson MS.
Yingjie ChenDepartment of Physiology and Biophysics University of Mississippi Medical Center, School of Medicine Jackson MS.ORCID 0000-0002-4059-7847
Jian-Xiong ChenDepartment of Pharmacology and Toxicology University of Mississippi Medical Center, School of Medicine Jackson MS.ORCID 0000-0001-9203-4336

Funding

Endothelial PHD2 in hypertensive vascular remodelingR01HL151536 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI CHEN, JIAN-XIONG · 2021 to 2024
$1.6M
NHLBI NIH HHS R01 HL151536
6 · The paper itself

Abstract

backgroundEndothelial prolyl hydroxylase-2 (PHD2) is essential for pulmonary remodeling and hypertension. In the present study, we investigated the role of endothelial PHD2 in angiotensin II-mediated arterial stiffness, pericyte recruitment, and cardiac fibrosis. METHODS AND

resultsChondroitin sulfate proteoglycan 4 tracing reporter chondroitin sulfate proteoglycan 4- red fluorescent protein (DsRed) transgenic mice were crossed with PHD2

conclusionsKnockout of endothelial PHD2 enhanced angiotensin II-induced cardiac fibrosis by mechanisms involving increasing arterial stiffness and pericyte-myofibroblast cell transitions.

Indexed as

Angiotensin IIEndothelial CellsFibrosisMice, KnockoutPericytesVascular StiffnessAnimalsDisease Models, AnimalHypoxia-Inducible Factor-Proline DioxygenasesMaleMiceMice, Inbred C57BLMyocardiumAngiotensin IIEgln1 protein, mouseHypoxia-Inducible Factor-Proline Dioxygenasesangiotensin IIarterial stiffnesscardiac fibrosispericytesprolyl hydroxylase‐2

Identifiers

PMID39056332
PMCPMC11963933

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.