ArticleJournal of the American Heart Association2024
Obstructive Sleep Apnea, Platelet Aggregation, and Cardiovascular Risk.
Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between obstructive sleep apnea and female sexual dysfunction: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2025Pooled it
- Cardiovascular Diseases: Exploring Epidemiology, Pathophysiology, Risk Factors, and Medicinal Plant-Based Therapies: A Narrative Review.Health science reports · 2026Article
- TGF‑β1 in obstructive sleep apnea: linking intermittent hypoxia, upper‑airway remodeling, and systemic comorbidities.Sleep & breathing = Schlaf & Atmung · 2026Review
- Association between hemoglobin and all-cause mortality in patients with obstructive sleep apnea and hypertension: insights from an observational study.Journal of human hypertension · 2026Observational
- Advances in cardiovascular risk assessment indicators in obstructive sleep apnea.Frontiers in public health · 2026Review
- Development and Validation of a Nomogram Incorporating Platelet Distribution Width and the Triglyceride-Glucose Index for Predicting Obstructive Sleep Apnea.Nature and science of sleep · 2026Article
- Association of Platelet Aggregation With Markers of Alzheimer Disease Pathology in Middle-Aged Participants of the Framingham Heart Study.Neurology · 2025Article
- Role of Free Radicals in the Pathophysiology of OSA: A Narrative Review of a Double-Edged Sword.Journal of clinical medicine · 2025Review
- Risk factors for pulmonary embolism: a case-control study.Journal of thoracic disease · 2025Article
- The Role of Depression in Linking Sleep Quality and Life Quality in OSAHS Patients.International journal of general medicine · 2025Article
- SHAP Analysis of Machine Learning-Based Carotid Atherosclerosis Prediction of Older Adults with OSA, a Multicenter Study.Nature and science of sleep · 2025Article
- White Matter Imaging Phenotypes Mediate the Negative Causality of Mitochondrial DNA Copy Number on Sleep Apnea: A Bidirectional Mendelian Randomization Study and Mediation Analysis.Nature and science of sleep · 2024Article
- Phase-Amplitude Coupling in Theta and Beta Bands: A Potential Electrophysiological Marker for Obstructive Sleep Apnea.Nature and science of sleep · 2024Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundAlthough related, the precise mechanisms linking obstructive sleep apnea (OSA) and cardiovascular disease (CVD) are unclear. Platelets are mediators of CVD risk and thrombosis and prior studies suggested associations of OSA and platelet activity. The aim of this study is to assess the link between OSA, platelet activity, and CVD-related risk factors. METHODS AND
resultsWe studied the association of OSA-measures and platelet aggregation in participants dually enrolled in the SHHS (Sleep Heart and Health Study) and FHS (Framingham Heart Study). We applied linear regression models with adjustment for demographic and clinical covariates and explored interactions with OSA and CVD-related factors, including age, sex, body mass index, hypertension, OSA diagnosis (apnea-hypopnea index 4%≥5), and aspirin use. Our final sample was of 482 participants (60 years [14.00], 50.4% female). No associations were observed between apnea-hypopnea index 4% and platelet aggregation in the main sample. Stratified analysis revealed an association in aspirin users (n=65) for our primary exposure (apnea-hypopnea index 4%, β=0.523;
conclusionsNo associations were detected between OSA and platelet aggregation in a community sample. Our finding that OSA associates with increased platelet aggregation in the aspirin group, most of whom use it for primary prevention of CVD, suggests that platelet aggregation may mediate the adverse impact of OSA on vascular health in individuals with existing CVD risk, supporting further investigation.
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