Evidence map›Paper›PMID 39056299›Full record

ArticleThe Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association2025

Do Palatoplasty Procedures Resolve Hypernasality as Effectively as Pharyngoplasty Procedures in Patients with 22q11.2 Deletion Syndrome?

Jessica L Williams, Jamie L Perry, Davinder J Singh, Thomas J Sitzman

Abstract read
In one paragraph

Article in The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Management of Persistent Hypernasality After Pharyngeal Flap by Revision Palatoplasty With Use of MRI to Aid Surgical Decision Making.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jessica L WilliamsPhoenix Children's Center for Cleft and Craniofacial, Phoenix Children's Hospital, Phoenix, AZ, USA.ORCID 0000-0002-2882-7275
Jamie L PerryDepartment of Communication Sciences and Disorders, East Carolina University, Greenville, NC, USA.ORCID 0000-0001-7866-9159
Davinder J SinghPhoenix Children's Center for Cleft and Craniofacial, Phoenix Children's Hospital, Phoenix, AZ, USA.
Thomas J SitzmanPhoenix Children's Center for Cleft and Craniofacial, Phoenix Children's Hospital, Phoenix, AZ, USA.ORCID 0000-0002-2173-923X

Funding

Velopharyngeal insufficiency following cleft palate repair: a comparative effectiveness study of existing surgical procedures and identification of criteria to guide a personalized treatment approachU01DE029750 · NIDCR · PHOENIX CHILDREN'S HOSPITAL · PI SITZMAN, THOMAS JAMES · 2020 to 2024
$4.2M
Understanding and Reducing Variation in Outcomes of Cleft Lip and Palate SurgeryK23DE025023 · NIDCR · PHOENIX CHILDREN'S HOSPITAL · PI SITZMAN, THOMAS JAMES · 2016 to 2020
$598k
NIDCR NIH HHS K23 DE025023NIDCR NIH HHS U01 DE029750
6 · The paper itself

Abstract

ObjectiveCompare the effectiveness of palatoplasty and pharyngoplasty procedures at resolving hypernasality in patients with 22q11.2 deletion syndrome (22q).DesignRetrospective cohort study.SettingMetropolitan children's hospital.PatientsFourteen patients with 22q presenting for management of velopharyngeal insufficiency.InterventionsPalatoplasty or pharyngoplasty procedure.Main Outcome MeasureResolution of hypernasality 12 months postoperatively.ResultsBoth procedure groups had a mean preoperative velopharyngeal gap of 6.2 mm during phonation. No patient who underwent palatoplasty achieved resolution of hypernasality; 1/7 patients had worse hypernasality, 4/7 had no change, and 2/7 had improved hypernasality. In contrast, hypernasality was resolved in 6/7 patients in the pharyngoplasty group, which was significantly (

Indexed as

DiGeorge SyndromePalate, SoftPharynxPlastic Surgery ProceduresVelopharyngeal InsufficiencyVoice DisordersAdolescentChildChild, PreschoolCohort StudiesFemaleHumansMaleTreatment OutcomehypernasalityMRIpharyngeal flappharyngoplastyresonancespeech assessmentsphincter pharyngoplastysurgical techniquesyndromevelocardiofacial syndromevelopharyngeal function

Identifiers

PMID39056299
PMCPMC11762359

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.