Evidence map›Paper›PMID 39056292›Full record

ArticleeLife2024

SPAG7 deletion causes intrauterine growth restriction, resulting in adulthood obesity and metabolic dysfunction.

Stephen E Flaherty, Olivier Bezy, Brianna LaCarubba Paulhus, LouJin Song, Mary Piper, Jincheng Pang, Yoson Park, Shoh Asano, Yu-Chin Lien, John D Griffin and 8 more

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Childhood obesity from the genes to the epigenome.Frontiers in endocrinology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Stephen E FlahertyInternal Medicine Research Unit, Pfizer Inc, Cambridge, United States.ORCID https://orcid.org/0000-0002-5050-6451
Olivier BezyInternal Medicine Research Unit, Pfizer Inc, Cambridge, United States.
Brianna LaCarubba PaulhusInternal Medicine Research Unit, Pfizer Inc, Cambridge, United States.
LouJin SongInternal Medicine Research Unit, Pfizer Inc, Cambridge, United States.ORCID https://orcid.org/0000-0002-1646-8121
Mary PiperInternal Medicine Research Unit, Pfizer Inc, Cambridge, United States.ORCID https://orcid.org/0000-0003-2699-3840
Jincheng PangInternal Medicine Research Unit, Pfizer Inc, Cambridge, United States.
Yoson ParkInternal Medicine Research Unit, Pfizer Inc, Cambridge, United States.
Shoh AsanoInternal Medicine Research Unit, Pfizer Inc, Cambridge, United States.
Yu-Chin LienCenter for Research on Reproduction and Women's Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
John D GriffinInternal Medicine Research Unit, Pfizer Inc, Cambridge, United States.
Andrew RobertsonDrug Safety Research and Development, Pfizer Inc, Groton, United States.
Alan OpsahlDrug Safety Research and Development, Pfizer Inc, Groton, United States.
Dinesh Hirenallur ShanthappaInternal Medicine Research Unit, Pfizer Inc, Cambridge, United States.
Youngwook AhnMedicine Design, Pfizer Inc, Cambridge, United States.
Evanthia PashosInternal Medicine Research Unit, Pfizer Inc, Cambridge, United States.
Rebecca A SimmonsCenter for Research on Reproduction and Women's Health, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States.
Morris J BirnbaumInternal Medicine Research Unit, Pfizer Inc, Cambridge, United States.
Zhidan WuInternal Medicine Research Unit, Pfizer Inc, Cambridge, United States.ORCID https://orcid.org/0000-0001-7289-9420

Funding

Pfizer Pharmaceuticals Research and Development
6 · The paper itself

Abstract

From a forward mutagenetic screen to discover mutations associated with obesity, we identified mutations in the

Indexed as

Fetal Growth RetardationMice, KnockoutObesityAnimalsEnergy MetabolismFemaleGene DeletionGlucose IntoleranceMicePregnancydevelopmental biologyembryonic developmentinsulin resistanceintrauterine growth restrictionmedicinemouseobesitySPAG7

Identifiers

PMID39056292
PMCPMC11281781

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.