Evidence map›Paper›PMID 39056276›Full record

ArticleeLife2024

The scheduling of adolescence with Netrin-1 and UNC5C.

Daniel Hoops, Robert Kyne, Samer Salameh, Del MacGowan, Radu Gabriel Avramescu, Elise Ewing, Alina Tao He, Taylor Orsini, Anais Durand, Christina Popescu and 7 more

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Genes · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Daniel HoopsDepartment of Psychiatry, McGill University, Montréal, Canada.ORCID https://orcid.org/0000-0002-5707-3513
Robert KyneNeuroscience Program, University at Buffalo, SUNY, United States.
Samer SalamehDouglas Mental Health University Institute, Montréal, Canada.
Del MacGowanDouglas Mental Health University Institute, Montréal, Canada.
Radu Gabriel AvramescuDepartment of Psychiatry, McGill University, Montréal, Canada.
Elise EwingDouglas Mental Health University Institute, Montréal, Canada.
Alina Tao HeDouglas Mental Health University Institute, Montréal, Canada.
Taylor OrsiniDouglas Mental Health University Institute, Montréal, Canada.
Anais DurandDouglas Mental Health University Institute, Montréal, Canada.ORCID https://orcid.org/0000-0001-8125-1394
Christina PopescuDouglas Mental Health University Institute, Montréal, Canada.
Janet Mengyi ZhaoDouglas Mental Health University Institute, Montréal, Canada.
Kelcie ShatzDepartment of Psychology, University at Buffalo, SUNY, United States.
LiPing LiDepartment of Psychology, University at Buffalo, SUNY, United States.
Quinn CarrollDepartment of Psychology, University at Buffalo, SUNY, United States.
Guofa LiuDepartment of Biological Sciences, University of Toledo, Toledo, United States.
Matthew J PaulNeuroscience Program, University at Buffalo, SUNY, United States.ORCID https://orcid.org/0000-0002-9097-1390
Cecilia FloresDepartment of Psychiatry, McGill University, Montréal, Canada.ORCID https://orcid.org/0000-0001-8606-5910

Funding

Amphetamine in adolescence disrupts frontal cortex developmentR01DA037911 · NIDA · MCGILL UNIVERSITY · PI FLORES, CECILIA · 2015 to 2024
$2.5M
CIHR FRN: 156272CIHR FRN: 170130National Science and Engineering Research Council of Canada RGPIN-2020-04703National Science Foundation IOS-1754878NIDA NIH HHS R01 DA037911NIDA NIH HHS R01DA037911
6 · The paper itself

Abstract

Dopamine axons are the only axons known to grow during adolescence. Here, using rodent models, we examined how two proteins, Netrin-1 and its receptor, UNC5C, guide dopamine axons toward the prefrontal cortex and shape behaviour. We demonstrate in mice (

Indexed as

Netrin-1Netrin ReceptorsAnimalsAxonsDopaminergic NeuronsFemaleMaleMicePhodopusPrefrontal CortexNetrin-1Netrin ReceptorsNtn1 protein, mouseUnc5c protein, mouseaxonal pathfindingbehavioural inhibitiondopamine systemmouseneurodevelopmentneuroscienceprefrontal cortexsiberian hamster

Identifiers

PMID39056276
PMCPMC11281785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.